MK-677

“"MK-677 can more than double circulating cortisol levels — that is a significant concern for long-term use"”

MK-677 (Ibutamoren) is an oral GH secretagogue that mimics ghrelin to stimulate GH and IGF-1 release. Huberman groups it in a cautious category due to significant side effects: elevated cortisol (can more than double circulating cortisol), elevated prolactin causing libido suppression and fluid retention, increased hunger and anxiety. It is the only non-injectable option in this class, which is its primary advantage.

“"MK-677 is as strong as injectable GH peptides, but it is much cheaper, does not need refrigeration, and does not need to be injected"”

Derek covers MK-677 as the only orally bioavailable GH secretagogue — no injections needed, no refrigeration, no PCT required. Typical doses range from 12.5–25 mg/day. Must be cycled due to diminishing returns and long-term blood glucose elevation risk (insulin resistance). Side effects include increased hunger (via ghrelin), water retention, and early lethargy. Derek rates it cautiously positive for those seeking GH benefits without needles, but emphasizes monitoring blood glucose and not running it continuously.