GHK-Cu
Overview
GHK-Cu is a naturally occurring tripeptide (Glycine-Histidine-Lysine) bound to copper (Cu²⁺), first identified in human plasma in 1973. Plasma levels decline ~60% between ages 20 and 60. Mechanistically, GHK-Cu stimulates fibroblast synthesis of collagen types I, III, and IV; increases elastin and glycosaminoglycan production; upregulates growth factors (FGF, PDGF, TGF-β); and exerts antioxidant effects via superoxide dismutase activation. Research at the Broad Institute found GHK-Cu modulated approximately 31% of the human genome toward a regenerative, anti-inflammatory expression pattern. Clinical evidence exists for topical application (skin aging, wound healing); systemic injectable evidence is predominantly preclinical. Topical cosmetic use is widely available; injectable form is a research compound. Consult a licensed physician before systemic use.
Dosage
2 mg · Any time · Can take on empty stomach
Scientific Sources
Frequently Asked Questions
What is GHK-Cu used for?
GHK-Cu is a naturally occurring tripeptide (Glycine-Histidine-Lysine) bound to copper (Cu²⁺), first identified in human plasma in 1973.
What is the recommended dosage for GHK-Cu?
2 mg. Any time. Can take on empty stomach.
Does GHK-Cu interact with other supplements?
No verified interactions found for GHK-Cu in our database yet.
When is the best time to take GHK-Cu?
Any time. Can take on empty stomach.
Is GHK-Cu safe to combine with other supplements?
Always check interactions before combining supplements. Use VitalStack to verify your full stack for free.
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