Modafinil
Overview
Modafinil is a eugeroic (wakefulness-promoting) pharmaceutical, distinct from classical stimulants. Its primary mechanism involves inhibition of dopamine reuptake transporters and activation of the orexin/hypocretin system, producing sustained wakefulness without the adrenergic surge of amphetamines. Approved for narcolepsy, obstructive sleep apnea, and shift work sleep disorder. Used off-label for cognitive enhancement, fatigue reduction, and jet lag adjustment. Half-life is 12–15 hours. Unlike methylphenidate, it has low abuse potential and minimal crash effect. Relevant stack interactions include CYP3A4 induction (reduces levels of hormonal contraceptives, some supplements); it may also reduce efficacy of cyclosporine. Cognitive enhancement effects are most pronounced in sleep-deprived individuals; evidence for enhancement in non-sleep-deprived populations is more limited.
Dosage
See product label · Morning · Can take on empty stomach
Key Interactions
1 verified interaction found
Both caffeine and modafinil promote wakefulness via different mechanisms. Their combination may produce excessive stimulation, anxiety, elevated heart rate, and severe sleep disruption. Clinical benefit of combining is not established.
Avoid or use only at low doses of each. Monitor cardiovascular symptoms. Do not use after midday.
View details →Scientific Sources
- Pitolisant versus placebo or modafinil in patients with narcolepsy. (Lancet Neurol, 2013 Nov)
- Cognitive enhancement effects of stimulants: a randomized controlled trial testing methylphenidate, modafinil, and caffeine. (Psychopharmacology, 2021 Feb)
- Update on the treatment of idiopathic hypersomnia. (Sleep Med Rev, 2023 Jun)
- Phase NA | COMPLETED | French Study on Cognitive Enhancement and Consumption of Psychoactive Substances
- Phase PHASE4 | COMPLETED | Targeting Circadian and Cognitive Dysfunction in Bipolar Disorder With Modafinil
- FDA approved | Provigil | NDA020717
- PubChem Compound 4236
Frequently Asked Questions
What is Modafinil used for?
Modafinil is a eugeroic (wakefulness-promoting) pharmaceutical, distinct from classical stimulants.
Does Modafinil interact with other supplements?
Modafinil has 1 verified interactions. Top: Caffeine.
When is the best time to take Modafinil?
Morning. Can take on empty stomach.
Is Modafinil safe to combine with other supplements?
Always check interactions before combining supplements. Use VitalStack to verify your full stack for free.
Check how Modafinil fits your full stack
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Check Your Stack →Not medical advice. VitalStack is not a medical device. For personalized health recommendations, consult a healthcare provider.