Sermorelin
Overview
Sermorelin is a synthetic analogue of endogenous Growth Hormone Releasing Hormone (GHRH), comprising its first 29 amino acids (GHRH 1-29 NH₂). It binds GHRH receptors on pituitary somatotrophs, stimulating pulsatile endogenous GH secretion and subsequent IGF-1 production. Unlike exogenous HGH, it preserves the natural pulsatility of GH release. Clinical studies in adults have used doses of 200–500 mcg. Previously FDA-approved as a diagnostic agent for GH deficiency (Geref); currently available only through compounding pharmacies. Synergistic with GHRP agents such as Ipamorelin in research settings. Evening timing is used in most study protocols due to alignment with natural GH pulsatility. Consult a licensed physician before use.
Dosage
300 mcg · Evening · Can take on empty stomach
Key Interactions
1 verified interaction found
Sermorelin (GHRH 1-29) and Ipamorelin act on different pituitary receptors — GHRH-R and GHSR-1a respectively — producing synergistic GH release. Research shows this combination achieves greater GH pulse amplitude than either compound alone, due to additive signaling at the pituitary somatotroph level.
This combination is used in compounding research settings. Both are unapproved compounds for general use. Consult a licensed physician.
View details →What Experts Say
“"It made the sleep in the early part of my night very, very deep...but I wasn't getting nearly as much rapid eye movement sleep"”
Sermorelin is an FDA-approved synthetic mimic of GHRH (growth hormone releasing hormone), prescribed off-label for adults. Huberman discloses personal use: 200–400 mcg subcutaneously 3–5× per week, taken at night on an empty stomach. He reports deep sleep improvements but notes it suppresses REM sleep, which led him to discontinue frequent use. Must avoid food 1.5–2 hours before and 30 min after injection.
“"Sermorelin — people just don't really get the results they want out of it and it's more anecdote than any kind of literature that points to it being sub-efficacious."”
Derek (MPMD) tells Peter Attia that Sermorelin underperforms in practice: anecdotally people don't get the results they expect, and there is little literature clearly explaining why. In clinics, Tessamorelin + Ipamorelin has become the preferred GHRH/GHRP combo, largely replacing Sermorelin.
Scientific Sources
Frequently Asked Questions
What is Sermorelin used for?
Sermorelin is a synthetic analogue of endogenous Growth Hormone Releasing Hormone (GHRH), comprising its first 29 amino acids (GHRH 1-29 NH₂).
What is the recommended dosage for Sermorelin?
300 mcg. Evening. Can take on empty stomach.
Does Sermorelin interact with other supplements?
Sermorelin has 1 verified interactions. Top: Ipamorelin.
When is the best time to take Sermorelin?
Evening. Can take on empty stomach.
Is Sermorelin safe to combine with other supplements?
Always check interactions before combining supplements. Use VitalStack to verify your full stack for free.
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