Testosterone

Overview

Testosterone is the primary male sex hormone (androgen), also present in smaller amounts in women. It regulates muscle mass, bone density, erythropoiesis, libido, mood, cognitive function, and metabolic health. Clinically, testosterone replacement therapy (TRT) is indicated for hypogonadism (typically defined as total testosterone below 300 ng/dL with associated symptoms). Common pharmaceutical forms include Testosterone Cypionate and Enanthate (injectable esters) and transdermal gels. Low-dose, high-frequency administration (e.g., 2–3 injections per week) produces more stable serum levels than single weekly bolus dosing, reducing side effects such as mood swings and erythrocytosis risk. Key monitoring parameters include total and free testosterone, estradiol (E2), hematocrit, PSA, and lipid profile. HCG co-administration preserves testicular function and endogenous production. Aromatase inhibitors (anastrozole) are occasionally used to manage estrogen conversion but carry risks including joint pain and cognitive effects. Lifestyle factors — sleep, resistance training, body composition, stress management — have significant impact on endogenous levels and should be optimized before or alongside TRT.

Dosage

See product label · Any time · Can take on empty stomach

Scientific Sources

• PubChem Compound 6013

Frequently Asked Questions