Acetylglucosamine
Overview
N-Acetylglucosamine (C8H15NO6) is the acetylated glucosamine derivative and building block of hyaluronic acid, heparan sulfate, and intestinal mucins. It enters the hexosamine biosynthesis pathway as UDP-GlcNAc for glycosaminoglycan synthesis. A meta-analysis of SYSADOAs found glucosamine-class compounds significantly improve pain and function in knee osteoarthritis, non-inferior to pharmacological treatment for 12 months. Also studied for gut mucosal repair and skin hyaluronic acid support. Shellfish-derived — fungal sources available for allergen-sensitive individuals.
Dosage
500 mg · Any time · Can take on empty stomach
Key Interactions
10 verified interactions found
Glycine substitution reduces sugar and sugar-like molecule binding in enzymes.
Glycin beeinflusst bestimmte Enzyme, die auch N-Acetylglucosamin verarbeiten; die Interaktion ist biochemisch beschrieben. Eine klinisch relevante Wechselwirkung bei Supplementdosierungen ist nicht belegt.
View details →Thiamine derivatives block the enzyme that removes sugar modifications from proteins during meiosis.
Thiamin und O-GlcNAc-Cycling interagieren laut präklinischer Daten in der meiotischen Reifung. Eine gleichzeitige Einnahme ist unbedenklich; klinische Relevanz ist nicht belegt.
View details →Rhamnosyl and N-acetylglucosaminyl glycosylation affects antigen structure and immune recognition.
Die Wechselwirkung zwischen Catechin und N-Acetylglucosamin basiert auf biochemisch indirekten Daten. Eine klinisch relevante Interaktion ist nicht belegt; eine gemeinsame Einnahme gilt als unbedenklich.
View details →Vitamin A and N-acetylglucosamine have synergistic effects on hyaluronic acid production, promoting skin hydration and structural integrity.
N-Acetylglucosamin und Retinoide wie Retinol können laut präklinischer Daten synergistisch die Hyaluronsäure-Produktion fördern. Eine gleichzeitige Einnahme ist unbedenklich.
View details →Melatonin inhibits elevated O-GlcNAc levels in bladder cancer cells, potentially suppressing cancer-associated glycosylation changes.
Melatonin kann erhöhte O-GlcNAc-Spiegel in Krebszellen hemmen; die klinische Relevanz für Supplement-Anwender ist nicht gesichert. Eine gleichzeitige Einnahme gilt als unbedenklich.
View details →Scientific Sources
- PubChem CID:1738118
- Effectiveness and Safety of SYSADOAs Used in Eastern and Western Regions for the Treatment... (Medicina (Kaunas), 2025 Feb 13)
- Roles of active site tryptophans in substrate binding and catalysis by alpha-1,3 (2004)
- Disruption of O‐GlcNAc homeostasis during mammalian oocyte meiotic maturation im (2019)
- Synergistic Effect of N-Acetylglucosamine and Retinoids on Hyaluronan Production (2004)
- Melatonin reduces proliferation and promotes apoptosis of bladder cancer cells b (2021)
- NIH Dietary Supplement Label Database (DSLD)
- PubChem Compound 1738118
Frequently Asked Questions
What is Acetylglucosamine used for?
N-Acetylglucosamine (C8H15NO6) is the acetylated glucosamine derivative and building block of hyaluronic acid, heparan sulfate, and intestinal mucins.
What is the recommended dosage for Acetylglucosamine?
500 mg. Any time. Can take on empty stomach.
Does Acetylglucosamine interact with other supplements?
Acetylglucosamine has 10 verified interactions. Top: Glycine, Vitamin B1 (Thiamin).
When is the best time to take Acetylglucosamine?
Any time. Can take on empty stomach.
Is Acetylglucosamine safe to combine with other supplements?
Always check interactions before combining supplements. Use VitalStack to verify your full stack for free.
Check how Acetylglucosamine fits your full stack
Verify interactions, get timing plans, and optimize your supplement routine — free.
Check Your Stack →Not medical advice. VitalStack is not a medical device. For personalized health recommendations, consult a healthcare provider.