Elderberry
Overview
Elderberry (Sambucus nigra) fruit extract is rich in anthocyanins (cyanidin-3-glucoside, cyanidin-3-sambubioside) and polysaccharides that activate dendritic cell-mediated T-cell immune responses. Doses of 300–600 mg/day (standardized to 15% anthocyanins) demonstrate moderate evidence for reducing cold/flu symptom duration and severity through enhanced cytokine production (IL-6, TNF-α, IFN-γ). Multiple RCTs support efficacy for upper respiratory viral infections. Caution with immunosuppressant medications (e.g., cyclosporine, corticosteroids): elderberry stimulates the immune system and may antagonize immunosuppressive therapy. Rare GI upset; no serious adverse events in healthy populations.
Dosage
300 mg · Any time · Take with food
Key Interactions
3 verified interactions found
Elderberry provides direct antiviral activity via neuraminidase inhibition; Echinacea stimulates innate immune response (macrophage activation, cytokine production). Different immune mechanisms.
Combine for cold/flu prevention and treatment.
View details →Elderberry anthocyanins have prebiotic-like effects; Probiotics support microbiome balance. Together they support gut-immune axis.
Combine for immune and gut health.
View details →Elderberry provides antiviral anthocyanins; Vitamin D3 modulates immune response. Together they support immune readiness.
Combine for immune support.
View details →Scientific Sources
- Source
- Source
- Elderberry + Echinacea combination study (PMID:37350689)
- Elderberry + Echinacea combination study (PMID:12455180)
- Elderberry + Probiotika combination study (PMID:38338593)
- Elderberry + Probiotika combination study (PMID:34100300)
- Elderberry + Vitamin D3 combination study (PMID:31364144)
Frequently Asked Questions
What is Elderberry used for?
Elderberry (Sambucus nigra) fruit extract is rich in anthocyanins (cyanidin-3-glucoside, cyanidin-3-sambubioside) and polysaccharides that activate dendritic cell-mediated T-cell immune responses.
What is the recommended dosage for Elderberry?
300 mg. Any time. Take with food.
Does Elderberry interact with other supplements?
Elderberry has 3 verified interactions. Top: Echinacea, Probiotika.
When is the best time to take Elderberry?
Any time. Take with food.
Is Elderberry safe to combine with other supplements?
Always check interactions before combining supplements. Use VitalStack to verify your full stack for free.
Check how Elderberry fits your full stack
Verify interactions, get timing plans, and optimize your supplement routine — free.
Check Your Stack →Not medical advice. VitalStack is not a medical device. For personalized health recommendations, consult a healthcare provider.