GABA (Gamma-Aminobuttersäure)
Overview
GABA (γ-aminobutyric acid, C4H9NO2) is the primary CNS inhibitory neurotransmitter. As an oral supplement, blood-brain barrier penetrance is limited and controversial. A study found improved temporal attention after oral GABA, possibly via peripheral receptors or enteric nervous system. Used for relaxation, anxiety, and sleep support. Generally well tolerated. Fermented GABA (PharmaGABA) may have better bioavailability. Additive sedation possible with alcohol and sedatives.
Dosage
500 mg · Evening · Can take on empty stomach
Key Interactions
4 verified interactions found
These herbal compounds enhance GABA activity. Combination with GABA supplements increases CNS depression.
Medical consultation recommended before combining multiple GABAergic substances.
View details →Both promote sleep — GABA via inhibitory neurotransmission, Melatonin via circadian signaling. Combined use may cause excessive sedation.
Low doses of each at bedtime only. Monitor for morning grogginess.
View details →GABA is the primary inhibitory neurotransmitter; Magnesium is a positive allosteric modulator of GABA-A receptors. Magnesium enhances GABA receptor sensitivity.
Combine for enhanced relaxation. Both evening-compatible.
View details →GABA directly activates inhibitory receptors; Ashwagandha mimics GABA at the receptor level and reduces cortisol. Complementary calming mechanisms.
Combine for stress and anxiety support.
View details →Scientific Sources
- Source
- Source
- GABA sleep promotion
- Melatonin circadian regulation
- GABA + magnesium receptor synergy study (1996)
- GABA magnesium sleep combination (2018)
- GABA + magnesium calming synergy review (2017)
- Ashwagandha male health — GABAergic mechanism discussion (2018)
- Ashwagandha neuropsychiatry — GABA receptor modulation (2022)
- Ashwagandha sleep-promoting — GABAergic activity (2023)
Frequently Asked Questions
What is GABA (Gamma-Aminobuttersäure) used for?
GABA (γ-aminobutyric acid, C4H9NO2) is the primary CNS inhibitory neurotransmitter.
What is the recommended dosage for GABA (Gamma-Aminobuttersäure)?
500 mg. Evening. Can take on empty stomach.
Does GABA (Gamma-Aminobuttersäure) interact with other supplements?
GABA (Gamma-Aminobuttersäure) has 4 verified interactions. Top: Bacopa monnieri, Melatonin.
When is the best time to take GABA (Gamma-Aminobuttersäure)?
Evening. Can take on empty stomach.
Is GABA (Gamma-Aminobuttersäure) safe to combine with other supplements?
Always check interactions before combining supplements. Use VitalStack to verify your full stack for free.
Check how GABA (Gamma-Aminobuttersäure) fits your full stack
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Check Your Stack →Not medical advice. VitalStack is not a medical device. For personalized health recommendations, consult a healthcare provider.