Reishi (Ganoderma lucidum)
Overview
Reishi (Ganoderma lucidum) contains ganoderic acid triterpenes and beta-glucans as primary bioactives. A systematic review identified 136 molecular cancer targets with immunostimulatory and anticancer mechanisms including cell cycle arrest and potential PD-L1 checkpoint inhibition. Beta-glucans provide immunomodulation. Also studied for hepatoprotection, stress adaptation, and sleep quality. Rare hepatotoxicity with long-term high-dose powder use — prefer standardized extracts. Antiplatelet activity — caution with anticoagulants. Generally well tolerated at standard doses.
Dosage
1000 mg · Any time · Take with food
Key Interactions
6 verified interactions found
Both are traditional immune-support herbs. Astragalus enhances T-cell and macrophage function; Reishi modulates NK cell activity via beta-glucans. Complementary immune pathways.
Combine for comprehensive immune support.
View details →Reishi beta-glucans activate innate immune cells (macrophages, NK cells); Vitamin D3 modulates adaptive immunity. Together they balance innate and adaptive immune responses.
Combine for immune system support.
View details →Reishi supports immune modulation and sleep quality; Lion's Mane supports cognitive function via NGF. Popular mushroom stack for brain + immune health.
Combine freely. Reishi evening (calming), Lion's Mane any time.
View details →Reishi supports immune modulation via beta-glucans; Vitamin C supports immune cell function. Both enhance immune response.
Combine for immune health.
View details →Reishi polysaccharides act as prebiotics supporting beneficial gut bacteria; Probiotics provide live beneficial organisms. Synbiotic effect.
Combine for gut-immune axis support.
View details →Scientific Sources
- Source
- Source
- Astragalus + Reishi (PMID:36352832)
- Astragalus + Reishi (PMID:18817878)
- Astragalus + Reishi (PMID:15351712)
- Reishi + Vitamin D3 combination study (PMID:34444885)
- Reishi + Vitamin D3 combination study (PMID:36671409)
- Reishi + Vitamin D3 combination study (PMID:14713328)
- Medicinal mushroom combination immune review (2023)
- Ganoderma + Hericium combination study (2012)
- Medicinal mushroom combination immune (2016)
- Reishi + Probiotika combination study (PMID:37427574)
Frequently Asked Questions
What is Reishi (Ganoderma lucidum) used for?
Reishi (Ganoderma lucidum) contains ganoderic acid triterpenes and beta-glucans as primary bioactives.
What is the recommended dosage for Reishi (Ganoderma lucidum)?
1000 mg. Any time. Take with food.
Does Reishi (Ganoderma lucidum) interact with other supplements?
Reishi (Ganoderma lucidum) has 6 verified interactions. Top: Astragalus (Astragalus membranaceus), Vitamin D3 (Cholecalciferol).
When is the best time to take Reishi (Ganoderma lucidum)?
Any time. Take with food.
Is Reishi (Ganoderma lucidum) safe to combine with other supplements?
Always check interactions before combining supplements. Use VitalStack to verify your full stack for free.
Check how Reishi (Ganoderma lucidum) fits your full stack
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Check Your Stack →Not medical advice. VitalStack is not a medical device. For personalized health recommendations, consult a healthcare provider.