Astragalus (Astragalus membranaceus)

Adaptogen Evidence: moderate

Overview

Astragalus (Astragalus membranaceus) contains astragalosides, cycloastragenol, polysaccharides, and flavonoids. Key mechanisms: immunomodulation, anti-inflammatory activity, and possible telomerase activation. A 2025 review confirmed Astragaloside IV promotes anti-inflammatory M2 macrophage polarization. Generally well tolerated. Caution in autoimmune diseases (immunostimulation may worsen conditions). May interfere with immunosuppressive medications. Cycloastragenol/TA-65 as telomerase activator — avoid in cancer patients. Limited long-term safety data.

Dosage

500 mg · Any time · Can take on empty stomach

Key Interactions

4 verified interactions found

Echinacea Info

Astragalus supports long-term immune resilience (tonic); Echinacea provides acute immune stimulation. Different temporal immune strategies.

Astragalus daily for maintenance; Echinacea short-term during illness.

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Reishi (Ganoderma lucidum) Info

Both are traditional immune-support herbs. Astragalus enhances T-cell and macrophage function; Reishi modulates NK cell activity via beta-glucans. Complementary immune pathways.

Combine for comprehensive immune support.

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Vitamin D3 (Cholecalciferol) Info

Astragalus polysaccharides enhance immune cell proliferation and telomerase activation; Vitamin D3 modulates immune tolerance. Complementary immune support.

Combine for immune health.

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Zink Info

Astragalus supports immune cell proliferation; Zinc is essential for T-cell development and function.

Combine for immune defense.

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Scientific Sources

Frequently Asked Questions

What is Astragalus (Astragalus membranaceus) used for?

Astragalus (Astragalus membranaceus) contains astragalosides, cycloastragenol, polysaccharides, and flavonoids.

What is the recommended dosage for Astragalus (Astragalus membranaceus)?

500 mg. Any time. Can take on empty stomach.

Does Astragalus (Astragalus membranaceus) interact with other supplements?

Astragalus (Astragalus membranaceus) has 4 verified interactions. Top: Echinacea, Reishi (Ganoderma lucidum).

When is the best time to take Astragalus (Astragalus membranaceus)?

Any time. Can take on empty stomach.

Is Astragalus (Astragalus membranaceus) safe to combine with other supplements?

Always check interactions before combining supplements. Use VitalStack to verify your full stack for free.

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Not medical advice. VitalStack is not a medical device. For personalized health recommendations, consult a healthcare provider.