Hesperidin
Overview
Hesperidin (C28H34O15, flavanone glycoside) is the predominant flavonoid in citrus peel, acting as a polyphenolic antioxidant with anti-inflammatory and vascular-protective properties. Mechanisms include modulation of NF-κB, COX-2, and neuroprotective pathways (BDNF upregulation). Clinical trials show modest improvements in endothelial function and blood flow; systematic reviews support neuroprotective effects in Parkinson's and Alzheimer's disease models. Often combined with diosmin for venous insufficiency (synergistic). Interactions: weak CYP3A4 inhibitor — caution with CYP3A4-dependent drugs (statins, immunosuppressants); potential mild additive effect with antihypertensives. Bioavailability low; enhanced by synergistic flavonoids and phospholipid complexation.
Dosage
250 mg · With meal · Take with food
Key Interactions
1 verified interaction found
Hesperidin enhances Vitamin C activity and capillary strength. Vitamin C regenerates oxidized hesperidin. Together they support vascular health.
Combine for vascular and antioxidant support.
View details →Scientific Sources
Frequently Asked Questions
What is Hesperidin used for?
Hesperidin (C28H34O15, flavanone glycoside) is the predominant flavonoid in citrus peel, acting as a polyphenolic antioxidant with anti-inflammatory and vascular-protective properties.
What is the recommended dosage for Hesperidin?
250 mg. With meal. Take with food.
Does Hesperidin interact with other supplements?
Hesperidin has 1 verified interactions. Top: Vitamin C (Ascorbic Acid).
When is the best time to take Hesperidin?
With meal. Take with food.
Is Hesperidin safe to combine with other supplements?
Always check interactions before combining supplements. Use VitalStack to verify your full stack for free.
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