Noopept
Overview
Noopept (N-phenylacetyl-L-prolylglycine ethyl ester, INN: omberacetam) is a synthetic dipeptide with nootropic and neuroprotective properties. Small Russian clinical trials report cognitive improvements in stroke and post-traumatic patients (20 mg/day, 2 months). It stimulates NGF and BDNF expression in the hippocampus. Evidence base is narrow — mostly Russian-language trials with limited international replication. Has been detected as an undeclared pharmaceutical ingredient in commercial supplements.
Dosage
10 mg · Morning · Can take on empty stomach
Key Interactions
4 verified interactions found
Piracetam and noopept share overlapping mechanisms (AMPA receptor modulation, cholinergic enhancement). Combining them provides no clear additive benefit and increases the demand for choline supplementation. Excessive glutamatergic stimulation is a theoretical risk.
Avoid combining without clear clinical indication. If stacking, ensure adequate choline supplementation.
View details →Caffeine and noopept are occasionally combined for acute cognitive enhancement. The combination may increase focus but also anxiety. Noopept's regulatory status means this combination carries additional legal risk depending on jurisdiction.
Use with caution. Low caffeine doses recommended. Note that noopept may not be legal as a supplement in your country.
View details →Noopept increases acetylcholine utilization in a manner similar to racetams. Alpha-GPC supplementation is recommended to prevent choline depletion headaches and sustain cognitive effects.
Stack noopept (10–20 mg) with alpha-GPC (150–300 mg) in the morning.
View details →Noopept stimulates NGF and BDNF expression in the hippocampus. Lion's Mane (hericenones, erinacines) independently promotes NGF synthesis. Their combination may produce complementary neuroprotective and neuroplasticity-enhancing effects.
Can be combined daily. No known adverse interactions. Evidence is preclinical — human data limited.
View details →Scientific Sources
Frequently Asked Questions
What is Noopept used for?
Noopept (N-phenylacetyl-L-prolylglycine ethyl ester, INN: omberacetam) is a synthetic dipeptide with nootropic and neuroprotective properties.
What is the recommended dosage for Noopept?
10 mg. Morning. Can take on empty stomach.
Does Noopept interact with other supplements?
Noopept has 4 verified interactions. Top: Piracetam, Caffeine.
When is the best time to take Noopept?
Morning. Can take on empty stomach.
Is Noopept safe to combine with other supplements?
Always check interactions before combining supplements. Use VitalStack to verify your full stack for free.
Check how Noopept fits your full stack
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Check Your Stack →Not medical advice. VitalStack is not a medical device. For personalized health recommendations, consult a healthcare provider.