Pregnenolon
Overview
Pregnenolone (C21H32O2) is an endogenous neurosteroid and precursor to all steroid hormones (DHEA, progesterone, cortisol, testosterone, estrogens). Modulates GABA-A and NMDA receptors. An 8-week RCT showed 300 mg pregnenolone reduced cocaine cue-induced craving and cocaine use vs. placebo. Investigational — limited evidence for wellness or cognitive use. Steroid precursor: may unpredictably alter downstream hormone levels. Contraindicated in hormone-sensitive cancers. Regulatory status varies by country. Hormone monitoring recommended.
Dosage
25 mg · Morning · Can take on empty stomach
Key Interactions
1 verified interaction found
Both are adrenal hormone precursors competing for enzymatic conversion; may create hormonal imbalance if combined
Do not combine DHEA with Pregnenolone; if using either, ensure adequate monitoring of hormone levels
View details →Scientific Sources
Frequently Asked Questions
What is Pregnenolon used for?
Pregnenolone (C21H32O2) is an endogenous neurosteroid and precursor to all steroid hormones (DHEA, progesterone, cortisol, testosterone, estrogens).
What is the recommended dosage for Pregnenolon?
25 mg. Morning. Can take on empty stomach.
Does Pregnenolon interact with other supplements?
Pregnenolon has 1 verified interactions. Top: DHEA (Dehydroepiandrosteron).
When is the best time to take Pregnenolon?
Morning. Can take on empty stomach.
Is Pregnenolon safe to combine with other supplements?
Always check interactions before combining supplements. Use VitalStack to verify your full stack for free.
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Check Your Stack →Not medical advice. VitalStack is not a medical device. For personalized health recommendations, consult a healthcare provider.