Rhodiola Rosea
Overview
Rhodiola rosea is an adaptogenic plant standardized to salidroside and rosavins. A literature review found acute supplementation (~200 mg before exercise) may improve endurance and time-to-exhaustion; higher doses benefit sprint and resistance training. Confirmed stress-modulatory, antioxidant, anti-fatigue, and immunomodulatory properties. Generally well tolerated; dizziness at higher doses. Mild stimulant effect — avoid in the evening. Possible MAO inhibition: caution with antidepressants. Standardized extracts preferred (3% rosavins, 1% salidroside).
Dosage
400 mg · Morning · Can take on empty stomach
Key Interactions
10 verified interactions found
Rhodiola supports energy and mood via monoamine modulation; Vitamin D3 supports serotonin synthesis via tryptophan hydroxylase activation. Complementary mood support.
Combine freely.
View details →Both are adaptogens acting on the HPA axis. Ashwagandha primarily lowers cortisol (GABA-mimetic), Rhodiola enhances stress tolerance via monoamine modulation. Complementary mechanisms without antagonism.
Can combine safely. Ashwagandha evening, Rhodiola morning for circadian alignment.
View details →Both are adaptogens. Schisandra protects the liver and enhances mental performance via lignan compounds; Rhodiola improves stress resilience via monoamine modulation. Classic adaptogen combination.
Combine for adaptogenic support. Both morning for energy.
View details →Rhodiola supports stress resilience; Magnesium supports GABA function and muscle relaxation. Complementary pathways for stress management.
Combine freely. Rhodiola morning, Magnesium evening.
View details →Rhodiola enhances mitochondrial efficiency; Creatine provides rapid ATP regeneration. Both support physical and cognitive performance under stress.
Combine for performance support.
View details →Scientific Sources
- Source
- Source
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- Rhodiola + Vitamin D3 combination study (PMID:35311615)
- Rhodiola + Vitamin D3 combination study (PMID:38213037)
- Rhodiola + Vitamin D3 combination study (PMID:40735481)
- Nootropic herbs and cognitive enhancers review (2023)
- Adaptogens on depression — systematic integrative review (2023)
- Adaptogenic herbs mechanisms and clinical evidence (2020)
- Schisandra + Rhodiola combination study (PMID:35337143)
- Schisandra + Rhodiola combination study (PMID:19188053)
- Rhodiola + Magnesium combination study (PMID:35565828)
- Rhodiola + Magnesium combination study (PMID:33896388)
- Rhodiola + Magnesium combination study (PMID:35938130)
- Rhodiola + creatine combination (2023)
- Rhodiola + creatine study (2021)
- NIH Dietary Supplement Label Database (DSLD)
- PubChem Compound 131410723
Frequently Asked Questions
What is Rhodiola Rosea used for?
Rhodiola rosea is an adaptogenic plant standardized to salidroside and rosavins.
What is the recommended dosage for Rhodiola Rosea?
400 mg. Morning. Can take on empty stomach.
Does Rhodiola Rosea interact with other supplements?
Rhodiola Rosea has 10 verified interactions. Top: Vitamin D3 (Cholecalciferol), Ashwagandha (KSM-66).
When is the best time to take Rhodiola Rosea?
Morning. Can take on empty stomach.
Is Rhodiola Rosea safe to combine with other supplements?
Always check interactions before combining supplements. Use VitalStack to verify your full stack for free.
Check how Rhodiola Rosea fits your full stack
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Check Your Stack →Not medical advice. VitalStack is not a medical device. For personalized health recommendations, consult a healthcare provider.