Vitamin B9 (Folate)
Overview
Folate (Vitamin B9) is a water-soluble vitamin essential for DNA synthesis, cell division, and amino acid metabolism. The synthetic supplement form is folic acid; the active form is L-methylfolate. Folate is especially important during pregnancy. Adults need 400 mcg daily; pregnant women need 600 mcg. The upper limit from supplements is 1,000 mcg per day. Individuals with the MTHFR gene variant may benefit from L-methylfolate directly. High doses can mask vitamin B12 deficiency.
Dosage
400 mcg · Morning · Take with food
Key Interactions
28 verified interactions found
High folate supplementation can mask pernicious anemia symptoms caused by B12 deficiency, delaying diagnosis of neurological damage. B12 deficiency may go undetected when folate levels are supplemented.
Check B12 status before high-dose folate supplementation. Ensure adequate B12 intake when using folate. Monitor for neurological symptoms.
View details →Folate and B12 are interdependent in the methionine synthase reaction. High-dose folate can mask the megaloblastic anemia of B12 deficiency, delaying diagnosis. Whether folate accelerates neurological damage is debated but the masking effect is well-established and clinically significant.
Always supplement B12 alongside high-dose folate. Monitor B12 status (MMA, homocysteine) regularly if taking folate >400 mcg/day.
View details →Green tea polyphenols interfere with folate absorption mechanisms (Alemdaroglu et al., 2008)
Separate doses by 2+ hours; monitor folate levels if taking folic acid supplementation
View details →Folic acid and niacin together enhance sperm viability during freeze-thaw preservation by protecting DNA integrity and energy metabolism.
Folsäure und Niacin (Vitamin B3) unterstützen gemeinsam Zellschutz- und Methylierungsprozesse. Die gleichzeitige Einnahme beider B-Vitamine ist bei empfohlenen Tagesdosen unbedenklich und nutritiv sinnvoll.
View details →Periconceptional choline supplementation may enhance folic acid's protective effects against neural tube birth defects.
Cholin und Folsäure ergänzen sich im Methylierungshaushalt komplementär. Kombination in üblichen Supplementdosen (Cholin ≤250mg, Folat ≤400mcg) ist unkritisch.
View details →Scientific Sources
- Source
- Correlation between sperm motility and sperm chromatin/DNA damage before and aft (2019)
- Implications of US Nutrition Facts Label Changes on Micronutrient Density of For (2017)
- Hydroxylation of prostaglandins A1 and E1 by liver microsomal monooxygenase. Cha (1978)
- Maternal choline concentrations during pregnancy and choline-related genetic var (2014)
- Disordered methionine/homocysteine metabolism in premature vascular disease. Its (1993)
- Studies on the precursors of the methyl groups of choline in rat liver. (1960)
- THE QUESTION OF THE RELATIVE IMPORTANCE OF PROTEIN AND LABILE METHYL IN THE DEVE (1954)
- NIH Dietary Supplement Label Database (DSLD)
- PubChem Compound 135398658
Frequently Asked Questions
What is Vitamin B9 (Folate) used for?
Folate (Vitamin B9) is a water-soluble vitamin essential for DNA synthesis, cell division, and amino acid metabolism.
What is the recommended dosage for Vitamin B9 (Folate)?
400 mcg. Morning. Take with food.
Does Vitamin B9 (Folate) interact with other supplements?
Vitamin B9 (Folate) has 28 verified interactions. Top: Vitamin B12 (Cobalamin), Vitamin B12 (Cobalamin).
When is the best time to take Vitamin B9 (Folate)?
Morning. Take with food.
Is Vitamin B9 (Folate) safe to combine with other supplements?
Always check interactions before combining supplements. Use VitalStack to verify your full stack for free.
Check how Vitamin B9 (Folate) fits your full stack
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Check Your Stack →Not medical advice. VitalStack is not a medical device. For personalized health recommendations, consult a healthcare provider.