Choline
Overview
Choline is an essential, water-soluble nutrient required for cell membrane integrity (phosphatidylcholine), acetylcholine synthesis, methyl donation, and lipid transport. Deficiency causes muscle damage and NAFLD. Adequate intake: 425 mg/day (women), 550 mg/day (men); upper limit: 3,500 mg/day. High doses increase TMAO, a metabolite linked to cardiovascular risk. Common forms: choline bitartrate, CDP-choline (citicoline), alpha-GPC. No known clinically relevant drug interactions.
Dosage
550 mg · Morning · Take with food
Key Interactions
30 verified interactions found
Cholin und Betain teilen gemeinsame Stoffwechselwege im Methylgruppen-Haushalt. Beide Substanzen erhöhen die intestinale TMA-Produktion, was TMAO-Spiegel und kardiovaskuläres Risiko beeinflussen kann.
Sowohl Cholin als auch Betain beeinflussen den Homocystein-Stoffwechsel; hohe Dosen beider Substanzen können sich addieren. Eine der beiden Substanzen ist für das Homocystein-Management ausreichend.
View details →Periconceptional choline supplementation may enhance folic acid's protective effects against neural tube birth defects.
Cholin und Folsäure ergänzen sich im Methylierungshaushalt komplementär. Kombination in üblichen Supplementdosen (Cholin ≤250mg, Folat ≤400mcg) ist unkritisch.
View details →Thiamin acetylates choline, enhancing synaptic nerve signal sensitivity.
Vitamin B1 fördert die Acetylierung von Cholin und kann so die cholinerge Signalübertragung unterstützen. Die Kombination beider Nährstoffe bei normaler Dosierung gilt als sicher und nutritiv sinnvoll.
View details →Choline supplementation increases alpha-tocopherol blood levels in dairy cows.
Cholin kann Vitamin-E-Plasmaspiegel erhöhen. Kombination in Standarddosen ist unkritisch; Gesamt-Vitamin-E-Zufuhr auf ≤300mg/Tag begrenzen.
View details →Oral CDP-choline (cytidine diphosphocholine) increases choline availability and enhances cognitive function in healthy volunteers, suggesting improved brain acetylcholine signaling.
Citicolin (CDP-Cholin) erhöht die Cholin-Spiegel; gleichzeitige Cholin-Supplementierung kann die Gesamtzufuhr erhöhen. Eine der beiden Quellen wählen; Gesamt-Cholinzufuhr auf ≤3,5g/Tag begrenzen.
View details →Scientific Sources
- Choline and Betaine Intakes Are Not Associated with Cardiovascular Disease Morta (2015)
- Association of choline and betaine levels with cancer incidence and survival: A (2019)
- Choline and Betaine Intake and Colorectal Cancer Risk in Chinese Population: A C (2015)
- Choline and betaine intakes are associated with reduced risk of nasopharyngeal c (2014)
- Choline and betaine intake is inversely associated with breast cancer risk: A tw (2013)
- Maternal choline concentrations during pregnancy and choline-related genetic var (2014)
- Disordered methionine/homocysteine metabolism in premature vascular disease. Its (1993)
- Studies on the precursors of the methyl groups of choline in rat liver. (1960)
- THE QUESTION OF THE RELATIVE IMPORTANCE OF PROTEIN AND LABILE METHYL IN THE DEVE (1954)
- The effect of aneurin on uterine contractions. (1953)
- In vivo and in vitro evidence for a common carrier mediated transport of choline (1990)
- Characterization of choline transport at maternal and fetal interfaces of the pe (1985)
- The inhibitory effect of choline and other quaternary ammonium compounds on thia (1985)
- Some properties of the thiamine uptake system in isolated rat hepatocytes. (1984)
- Rumen-protected choline administration to transition cows: effects on milk produ (2003)
- The influence of vitamin E on membrane lipids of mouse fibroblasts in culture. (1981)
- Choline and Fructooligosaccharide: Non-alcoholic Fatty Liver Disease, Cardiac Fa (2015)
- Neurocognitive effects of acute choline supplementation in low, medium and high (2015)
- Effective treatment of traumatic brain injury: learning from experience. (2012)
- Choline or CDP-choline attenuates coagulation abnormalities and prevents the dev (2010)
- Choline, CDP-choline or phosphocholine increases plasma glucagon in rats: involv (2008)
- Peripheral administration of CDP-choline, phosphocholine or choline increases pl (2008)
- NIH Dietary Supplement Label Database (DSLD)
- PubChem Compound 305
Frequently Asked Questions
What is Choline used for?
Choline is an essential, water-soluble nutrient required for cell membrane integrity (phosphatidylcholine), acetylcholine synthesis, methyl donation, and lipid transport.
What is the recommended dosage for Choline?
550 mg. Morning. Take with food.
Does Choline interact with other supplements?
Choline has 30 verified interactions. Top: Betaine, Vitamin B9 (Folate).
When is the best time to take Choline?
Morning. Take with food.
Is Choline safe to combine with other supplements?
Always check interactions before combining supplements. Use VitalStack to verify your full stack for free.
Check how Choline fits your full stack
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Check Your Stack →Not medical advice. VitalStack is not a medical device. For personalized health recommendations, consult a healthcare provider.