Citicholine
Overview
Citicoline (C14H26N4O11P2) is an endogenous phosphatidylcholine biosynthesis intermediate cleaved into cytidine and choline, both crossing the blood-brain barrier. A systematic review found citicoline improved cognitive status across multiple studies, though evidence quality is limited by methodological biases. Neuroprotective mechanisms include membrane phospholipid repair, dopamine receptor upregulation, and mitochondrial protection. Available as citicoline sodium. Excellent safety profile. Studied for stroke recovery, age-related cognitive decline, and ADHD. Additive with cholinesterase inhibitors.
Dosage
250 mg · Any time · Can take on empty stomach
Key Interactions
12 verified interactions found
Oral CDP-choline (cytidine diphosphocholine) increases choline availability and enhances cognitive function in healthy volunteers, suggesting improved brain acetylcholine signaling.
Citicolin (CDP-Cholin) erhöht die Cholin-Spiegel; gleichzeitige Cholin-Supplementierung kann die Gesamtzufuhr erhöhen. Eine der beiden Quellen wählen; Gesamt-Cholinzufuhr auf ≤3,5g/Tag begrenzen.
View details →CDP-Choline (Citicholine) fördert die Aufnahme von Tyrosin in striatalen Synaptosomen. Dies kann die Verfügbarkeit von Tyrosin als Dopamin-Vorläufer im Gehirn erhöhen.
CDP-Cholin kann laut präklinischer Daten die Tyrosin-Aufnahme in striatalen Synaptosomen fördern und damit die Dopamin-Verfügbarkeit erhöhen. Eine gleichzeitige Einnahme ist unbedenklich.
View details →Pre-treatment with CDP-choline significantly increases dopamine metabolite levels in the brain's reward center, suggesting enhanced dopamine signaling and potential cognitive or mood benefits.
Citicolin kann dopaminerge Stoffwechselwege beeinflussen, die auch durch Piperin moduliert werden. Eine gleichzeitige Einnahme gilt als unbedenklich.
View details →Both are cholinergic compounds that increase acetylcholine; combining may have additive effects
Avoid combining; choose one cholinergic compound to prevent excessive cholinergic effects
View details →CDP-Choline (Citicholine) fördert die Aufnahme von Tryptophan in striatalen Synaptosomen. Dies kann die Verfügbarkeit von Tryptophan als Serotonin-Vorläufer im Gehirn erhöhen.
CDP-Cholin kann laut präklinischer Daten die Tryptophan-Aufnahme in striatalen Synaptosomen fördern und damit die Serotonin-Verfügbarkeit erhöhen. Eine gleichzeitige Einnahme ist unbedenklich.
View details →Scientific Sources
- Neurocognitive effects of acute choline supplementation in low, medium and high (2015)
- Effective treatment of traumatic brain injury: learning from experience. (2012)
- Choline or CDP-choline attenuates coagulation abnormalities and prevents the dev (2010)
- Choline, CDP-choline or phosphocholine increases plasma glucagon in rats: involv (2008)
- Peripheral administration of CDP-choline, phosphocholine or choline increases pl (2008)
- Cytidine(5')diphosphocholine enhances the ability of haloperidol to increase dop (1984)
- pubmed
- NIH Dietary Supplement Label Database (DSLD)
- PubChem Compound 13804
Frequently Asked Questions
What is Citicholine used for?
Citicoline (C14H26N4O11P2) is an endogenous phosphatidylcholine biosynthesis intermediate cleaved into cytidine and choline, both crossing the blood-brain barrier.
What is the recommended dosage for Citicholine?
250 mg. Any time. Can take on empty stomach.
Does Citicholine interact with other supplements?
Citicholine has 12 verified interactions. Top: Choline, Tyrosine.
When is the best time to take Citicholine?
Any time. Can take on empty stomach.
Is Citicholine safe to combine with other supplements?
Always check interactions before combining supplements. Use VitalStack to verify your full stack for free.
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Check Your Stack →Not medical advice. VitalStack is not a medical device. For personalized health recommendations, consult a healthcare provider.