Tyrosine
Overview
Tyrosine (C9H11NO3) is a conditionally essential amino acid synthesized from phenylalanine; precursor to catecholamines (dopamine, noradrenaline, adrenaline), melanin, and thyroid hormones. A meta-analysis of 10 interventions found no significant effect of tyrosine supplementation on endurance performance versus placebo (low-moderate evidence). Individual studies suggest cognitive benefits under acute stress. Contraindicated with MAO inhibitors (hypertensive crisis risk). Caution with thyroid disease and active melanoma. No EFSA-authorized health claims.
Dosage
500 mg · Any time · Can take on empty stomach
Key Interactions
21 verified interactions found
Ein erhöhtes Phenylalanin/Tyrosin-Verhältnis weist auf verminderte Phenylalanin-Hydroxylase-Aktivität hin und kann die Tyrosin-abhängige Neurotransmittersynthese beeinträchtigen.
Phenylalanin ist die Vorstufe von Tyrosin; hohe Phenylalanin-Dosen können Tyrosin-Spiegel und -Verfügbarkeit beeinflussen. Bei gezielter Tyrosin-Supplementierung zeitversetzt einnehmen (mindestens 2h Abstand).
View details →In maple syrup urine disease (MSUD), elevated branched-chain amino acids like leucine can deplete tyrosine and tryptophan in the brain by competing for the same transporter, impairing dopamine and serotonin production.
Erhöhte BCAA-Spiegel (Leucin, Isoleucin, Valin) können Tyrosin-Verfügbarkeit im Gehirn reduzieren. Bei gezielter Tyrosin-Supplementierung mindestens 2h Abstand zu BCAA-Produkten einhalten.
View details →Folate helps balance amino acids by lowering excess phenylalanine and supporting serotonin production via tyrosine.
Folsäure kann über den Biopterin-Stoffwechselweg die Phenylalanin-zu-Tyrosin-Umwandlung fördern. Eine Kombination mit Tyrosin bei normaler Dosierung ist unbedenklich; bei Phenylketonurie oder Stoffwechselerkrankungen ärztliche Rücksprache erforderlich.
View details →Catechin polyphenols alter how the body processes tyrosine, an amino acid involved in stress hormone and neurotransmitter production.
Catechine können laut moderater Evidenz das Tyrosin-Plasmaprofil und dessen Verhältnis zu anderen Aminosäuren beeinflussen. Eine gemeinsame Einnahme ist unbedenklich.
View details →CDP-Choline (Citicholine) fördert die Aufnahme von Tyrosin in striatalen Synaptosomen. Dies kann die Verfügbarkeit von Tyrosin als Dopamin-Vorläufer im Gehirn erhöhen.
CDP-Cholin kann laut präklinischer Daten die Tyrosin-Aufnahme in striatalen Synaptosomen fördern und damit die Dopamin-Verfügbarkeit erhöhen. Eine gleichzeitige Einnahme ist unbedenklich.
View details →Scientific Sources
- Pegylated interferon-&agr;2b treatment in melanoma patients: influence on amino (2004)
- The beta-agonist cimaterol directly enhances chronic protein accretion in skelet (1998)
- Fyn‐dependent phosphorylation of PlexinA1 and PlexinA2 at conserved tyrosines is (2018)
- Post-Translational Incorporation of L-Phenylalanine into the C-Terminus of α-Tub (2016)
- Rate of Phenylalanine Hydroxylation in Healthy School-Aged Children (2011)
- Hepatocyte transplantation (HTx) corrects selected neurometabolic abnormalities (2009)
- Interactions of p59fyn and ZAP-70 with T-cell receptor activation motifs: defini (1994)
- Transport of benzenoid amino acids by system T and four broad scope systems in p (1990)
- Dietary amino acid precursors: Effects on central monoamines, aggression, and lo (1980)
- Evolution of glioblastoma (2009)
- A case of tetrahydrobiopterin deficiency due to a defective synthesis of dihydro (2005)
- The effect of folic acid on tyrosine metabolism in guinea pigs. (1962)
- An analysis of the interactions between folic acid and aromatic guest molecules (2018)
- Chemical modification of cysteine and tyrosine residues in formyltetrahydrofolat (1982)
- The effects of combined intravenous cocaine and ethanol self-administration on t (2020)
- Src‐protein tyrosine kinases are required for cocaine‐induced increase in the ex (2009)
- NIH Dietary Supplement Label Database (DSLD)
- PubChem Compound 6057
Frequently Asked Questions
What is Tyrosine used for?
Tyrosine (C9H11NO3) is a conditionally essential amino acid synthesized from phenylalanine; precursor to catecholamines (dopamine, noradrenaline, adrenaline), melanin, and thyroid hormones.
What is the recommended dosage for Tyrosine?
500 mg. Any time. Can take on empty stomach.
Does Tyrosine interact with other supplements?
Tyrosine has 21 verified interactions. Top: Phenylalanine, Leucine.
When is the best time to take Tyrosine?
Any time. Can take on empty stomach.
Is Tyrosine safe to combine with other supplements?
Always check interactions before combining supplements. Use VitalStack to verify your full stack for free.
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Check Your Stack →Not medical advice. VitalStack is not a medical device. For personalized health recommendations, consult a healthcare provider.