Piperin
Overview
Piperine is the main alkaloid in black pepper, primarily used as a bioavailability enhancer. It inhibits CYP3A4 and P-glycoprotein, reducing first-pass metabolism and increasing absorption of co-administered compounds (e.g., curcumin). A 2021 review noted dose-dependent toxicity, reproductive, and hepatic concerns at higher doses. Drug interaction potential is clinically relevant: CYP3A4 inhibition can increase blood levels of many medications. Generally safe at typical doses (5–10 mg/day). Contraindicated in pregnancy at higher doses.
Dosage
10 mg · With meal · Take with food
Key Interactions
16 verified interactions found
Piperine primarily inhibits Phase I CYP enzymes and UDP-glucuronosyltransferase, while sulforaphane activates Phase II detoxification via NRF2. The net effect of co-administration on sulforaphane efficacy is unclear due to lack of direct clinical studies.
Limited evidence for this specific combination. Consider separating intake by 2-4 hours if using both.
View details →Cobalt injection causes abnormal movement behavior, but effects are not related to piperin mechanisms.
Cobalt-Injektionen in die Substantia nigra zeigen dopaminerge Effekte; die klinische Relevanz für kombinierte Supplementierung ist nicht gesichert. Eine gleichzeitige Einnahme gilt als unbedenklich.
View details →Piperine inhibits hepatic and intestinal glucuronidation of curcumin, increasing its bioavailability by approximately 2000%. Without piperine, curcumin absorption is only about 1%.
Always take curcumin together with piperine (5-10 mg piperine per 500-1000 mg curcumin) for meaningful absorption.
View details →Pre-treatment with CDP-choline significantly increases dopamine metabolite levels in the brain's reward center, suggesting enhanced dopamine signaling and potential cognitive or mood benefits.
Citicolin kann dopaminerge Stoffwechselwege beeinflussen, die auch durch Piperin moduliert werden. Eine gleichzeitige Einnahme gilt als unbedenklich.
View details →Piperine enhances iron absorption through bioavailability enhancement properties
Take piperine with iron supplementation to improve absorption and reduce needed dosage
View details →Scientific Sources
Frequently Asked Questions
What is Piperin used for?
Piperine is the main alkaloid in black pepper, primarily used as a bioavailability enhancer.
What is the recommended dosage for Piperin?
10 mg. With meal. Take with food.
Does Piperin interact with other supplements?
Piperin has 16 verified interactions. Top: Sulforaphan, Cobalt.
When is the best time to take Piperin?
With meal. Take with food.
Is Piperin safe to combine with other supplements?
Always check interactions before combining supplements. Use VitalStack to verify your full stack for free.
Check how Piperin fits your full stack
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Check Your Stack →Not medical advice. VitalStack is not a medical device. For personalized health recommendations, consult a healthcare provider.