Curcumin
Overview
Curcumin is the primary bioactive polyphenol in turmeric (Curcuma longa), investigated for anti-inflammatory and antioxidant properties. Poor oral bioavailability limits clinical utility; piperine (black pepper) or lipid carrier formulations substantially increase absorption. Multiple case reports and a systematic review (Lombardi et al. 2021) link high-bioavailability curcumin supplements to drug-induced liver injury. May interact with anticoagulants and diabetes medications. No formal upper limit established.
Dosage
500 mg · With meal · Take with food
Key Interactions
24 verified interactions found
Piperine inhibits hepatic and intestinal glucuronidation of curcumin, increasing its bioavailability by approximately 2000%. Without piperine, curcumin absorption is only about 1%.
Always take curcumin together with piperine (5-10 mg piperine per 500-1000 mg curcumin) for meaningful absorption.
View details →Betaine enhances meat quality markers more effectively than equivalent glycine doses.
Betain und Curcumin können sich in ihrer Wirkung auf den Stoffwechsel ergänzen; die Evidenz basiert auf Tierstudien. Eine Kombination beider Supplemente gilt als unbedenklich.
View details →Choline supplementation during pregnancy reduces harmful anti-angiogenic factors, supporting healthy placental development and preventing pregnancy complications.
Cholin und Curcumin können sich in ihrer Wirkung auf Methylierungsprozesse und Entzündungsreaktionen ergänzen. Eine gleichzeitige Einnahme beider Supplemente gilt als unbedenklich.
View details →Curcumin exerts prebiotic-like effects modulating microbiome; Probiotics enhance gut health while curcumin reduces gut inflammation.
Combine for gut health.
View details →Curcumin and Vitamin E both have antioxidant and anti-inflammatory properties. Curcumin can promote glutathione synthesis which supports the Vitamin E antioxidant recycling network.
Can be taken together for complementary antioxidant support.
View details →Scientific Sources
- Dietary supplementation with betaine or glycine improves the carcass trait, meat (2021)
- A higher maternal choline intake among third‐trimester pregnant women lowers pla (2013)
- Curcumin + probiotics gut synergy (2025)
- Curcumin + probiotic combination study (2017)
- Curcumin probiotic gut health review (2024)
- Curcumin + vitamin E antioxidant synergy (2011)
- Curcumin + tocopherol combination (2017)
- Curcumin vitamin E antioxidant review (2016)
- NIH Dietary Supplement Label Database (DSLD)
- PubChem Compound 969516
Frequently Asked Questions
What is Curcumin used for?
Curcumin is the primary bioactive polyphenol in turmeric (Curcuma longa), investigated for anti-inflammatory and antioxidant properties.
What is the recommended dosage for Curcumin?
500 mg. With meal. Take with food.
Does Curcumin interact with other supplements?
Curcumin has 24 verified interactions. Top: Piperin, Betaine.
When is the best time to take Curcumin?
With meal. Take with food.
Is Curcumin safe to combine with other supplements?
Always check interactions before combining supplements. Use VitalStack to verify your full stack for free.
Check how Curcumin fits your full stack
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Check Your Stack →Not medical advice. VitalStack is not a medical device. For personalized health recommendations, consult a healthcare provider.