Vitamin E (Tocopherol)
Overview
Vitamin E is a fat-soluble antioxidant that protects cells from free radical damage and supports immune function. Alpha-tocopherol is the active form. Good sources include nuts, seeds, vegetable oils, and leafy greens. Adults need 15 mg (22.4 IU) daily. The upper limit is 1,000 mg per day. High doses may increase bleeding risk, especially with blood thinners. Long-term high-dose supplementation (400+ IU/day) has been associated with adverse effects in some studies.
Dosage
15 mg · With meal · Take with food
Key Interactions
44 verified interactions found
Vitamin E kann die intestinale Aufnahme von Vitamin D3 beeinträchtigen. Bei kombinierter hochdosierter Supplementierung sollte der Vitamin-D-Spiegel kontrolliert werden.
Hohe Vitamin-E-Konzentrationen können die Aufnahme von Vitamin D3 beeinträchtigen. Beide zeitversetzt einnehmen (mindestens 2h Abstand); bei normaler Supplementierung ist keine klinisch relevante Wechselwirkung zu erwarten.
View details →Gleichzeitige hochdosierte Vitamin-E-Einnahme kann die Plasma-CoQ10-Spiegel senken. Wer CoQ10 aus therapeutischen Gründen einnimmt, sollte hochdosiertes Vitamin E meiden.
Gleichzeitige hochdosierte Vitamin-E-Supplementierung kann den Plasma-CoQ10-Spiegel senken. Bei gezielter CoQ10-Supplementierung Vitamin E zeitversetzt einnehmen (mindestens 2h Abstand) für optimale CoQ10-Aufnahme.
View details →Vitamin E kann Mangan-induzierte neurotoxische Effekte auf das dopaminerge System teilweise reduzieren. Relevant bei arbeitsbedingter oder supplementierungsbedingter Mangan-Exposition.
Vitamin E kann manganinduzierte Neurotoxizität teilweise abpuffern. Mangan-Supplementierung auf notwendige Mengen begrenzen; dauerhaft hohe Mangandosen (>11mg/Tag) vermeiden.
View details →Quercetin partially blocks the absorption and use of vitamin E in the body.
Quercetin kann den oxidativen Verbrauch von Vitamin E reduzieren und so die Wirkung verlängern. Kombination in Standarddosen ist unkritisch; Gesamte antioxidative Einnahme im Blick behalten.
View details →Delta-Tocopherol und Resveratrol zeigen additive antiproliferative Effekte in Zellmodellen. Klinische Relevanz der Kombination bei Tumorpatienten ist noch nicht abschließend geklärt.
Delta-Tocopherol und Resveratrol können sich in bestimmten zellulären Wirkungen addieren. Kombination in Standarddosen (Vitamin E ≤300mg, Resveratrol ≤150mg/Tag) ist unkritisch; Hochdosen beider Substanzen kombiniert vermeiden.
View details →Scientific Sources
- Vitamin D intestinal absorption is not a simple passive diffusion: evidences for (2011)
- Correlation of serum vitamin A, D, and E with recurrent respiratory infection in (2019)
- Association of vitamin C, vitamin D, vitamin E and risk of bladder cancer: a dos (2015)
- Nutritional influences on age-related skeletal muscle loss (2013)
- Induction of the differentiation of HL-60 promyelocytic leukemia cells by curcum (1997)
- Coenzyme Q10: Absorption, Antioxidative Properties, Determinants, and Plasma Lev (2002)
- The importance of plasma membrane coenzyme Q in aging and stress responses. (2007)
- Therapeutic effects of coenzyme Q10 in neurodegenerative diseases. (2004)
- Interactions between ubiquinones and vitamins in membranes and cells. (1994)
- Hormonal and Metabolic Effects of Coenzyme Q10 and/or Vitamin E in Patients With (2019)
- Role of dopamine in manganese neurotoxicity (1988)
- The determination of the effect of some 1,3,4 thiadiazole derivatives on biochem (2018)
- Molecular mechanism of manganese exposure-induced dopaminergic toxicity (2008)
- Manganese induces cell swelling in cultured astrocytes. (2007)
- Vitamin E Protects Renal Antioxidant Enzymes and Attenuates Glomerulosclerosis i (2002)
- Inhibitory Effect of Flavonoids on Low‐Density Lipoprotein Peroxidation Catalyze (2000)
- Inhibition of mammalian 15-lipoxygenase-dependent lipid peroxidation in low-dens (1998)
- Modulation of human keratinocyte responses to solar UV by plant polyphenols as a (2013)
- Inhibition of photooxidation of alpha-tocopherol by quercetin in human blood cel (1991)
- [Effects of quercetin on photosensitized oxidation of alpha-tocopherol in human (1990)
- Enhanced anti‐proliferative effects of combinatorial treatment of δ ‐tocopherol (2007)
- On-line EPR study of free radicals induced by peroxidase/H(2)O(2) in human low-d (2002)
- Resveratrol regulates hyperglycemia-induced modulations in experimental diabetic (2018)
- Protective effect of resveratrol and vitamin E against ethanol-induced oxidative (2010)
- Liposomes as carriers of resveratrol and vitamin E: Evaluating ameliorative anti (2020)
- NIH Dietary Supplement Label Database (DSLD)
- PubChem Compound 14985
Frequently Asked Questions
What is Vitamin E (Tocopherol) used for?
Vitamin E is a fat-soluble antioxidant that protects cells from free radical damage and supports immune function.
What is the recommended dosage for Vitamin E (Tocopherol)?
15 mg. With meal. Take with food.
Does Vitamin E (Tocopherol) interact with other supplements?
Vitamin E (Tocopherol) has 44 verified interactions. Top: Vitamin D3 (Cholecalciferol), Ubiquinone.
When is the best time to take Vitamin E (Tocopherol)?
With meal. Take with food.
Is Vitamin E (Tocopherol) safe to combine with other supplements?
Always check interactions before combining supplements. Use VitalStack to verify your full stack for free.
Check how Vitamin E (Tocopherol) fits your full stack
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