Manganese
Overview
Manganese is an essential trace mineral and enzyme cofactor for amino acid, cholesterol, glucose, and carbohydrate metabolism, bone formation, and antioxidant defense. Adequate intake: 2.3 mg/day (men), 1.8 mg/day (women); upper limit: 11 mg/day. True deficiency is very rare. Significant toxicity risk: excess causes manganism — a neurotoxic syndrome with tremors, psychiatric symptoms, and Parkinson's-like motor impairment. Iron deficiency increases manganese absorption and toxicity risk.
Dosage
2 mg · Any time · Take with food
Key Interactions
24 verified interactions found
Vitamin E kann Mangan-induzierte neurotoxische Effekte auf das dopaminerge System teilweise reduzieren. Relevant bei arbeitsbedingter oder supplementierungsbedingter Mangan-Exposition.
Vitamin E kann manganinduzierte Neurotoxizität teilweise abpuffern. Mangan-Supplementierung auf notwendige Mengen begrenzen; dauerhaft hohe Mangandosen (>11mg/Tag) vermeiden.
View details →High manganese doses (100 mg/kg) reduce magnesium absorption and plasma levels; optimal ratio is 10-50 mg/kg
Avoid excessive manganese supplementation when taking magnesium; maintain proper dosing ratio
View details →Manganese and iron compete for absorption; lower manganese increases mineral bioavailability
Space manganese and iron supplementation; consider separate dose timing
View details →Quercetin protects against manganese toxicity by reducing apoptotic markers and preserving nerve cell viability.
Quercetin kann Mangan-induzierte Zellschäden reduzieren. Kombination in Standarddosen ist unkritisch; Mangan-Supplementierung generell auf notwendige Mengen begrenzen.
View details →Vitamin D3 treatment increases genes involved in managing zinc, manganese, and iron levels in the body, suggesting improved mineral homeostasis.
Vitamin D3 beeinflusst die Expression von Genen der Mangan-Homöostase. Kombination in Standarddosen ist unkritisch; Mangan-Supplementierung auf notwendige Mengen begrenzen.
View details →Scientific Sources
- PubChem CID:23930
- NIH Office of Dietary Supplements
- Role of dopamine in manganese neurotoxicity (1988)
- The determination of the effect of some 1,3,4 thiadiazole derivatives on biochem (2018)
- Molecular mechanism of manganese exposure-induced dopaminergic toxicity (2008)
- Manganese induces cell swelling in cultured astrocytes. (2007)
- Vitamin E Protects Renal Antioxidant Enzymes and Attenuates Glomerulosclerosis i (2002)
- pubmed
- Quercetin Attenuates Manganese-Induced Neuroinflammation by Alleviating Oxidativ (2017)
- Differential effects of dietary flavonoids on reactive oxygen and nitrogen speci (2008)
- The effect of quercetin on the mRNA expression of different antioxidant enzymes (2003)
- Interaction between Polyphenolic Antioxidants and Saccharomyces cerevisiae Cells (2020)
- Vitamin D3 transactivates the zinc and manganese transporter SLC30A10 via the Vi (2016)
- Performance and bone mineralisation in broiler chicks fed on diets with differen (2009)
- Vitamin D and manganese in the nutrition of the chick. (1967)
- NIH Dietary Supplement Label Database (DSLD)
- PubChem Compound 23930
Frequently Asked Questions
What is Manganese used for?
Manganese is an essential trace mineral and enzyme cofactor for amino acid, cholesterol, glucose, and carbohydrate metabolism, bone formation, and antioxidant defense.
What is the recommended dosage for Manganese?
2 mg. Any time. Take with food.
Does Manganese interact with other supplements?
Manganese has 24 verified interactions. Top: Vitamin E (Tocopherol), Magnesium Citrat.
When is the best time to take Manganese?
Any time. Take with food.
Is Manganese safe to combine with other supplements?
Always check interactions before combining supplements. Use VitalStack to verify your full stack for free.
Check how Manganese fits your full stack
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Check Your Stack →Not medical advice. VitalStack is not a medical device. For personalized health recommendations, consult a healthcare provider.