Betaine
Overview
Betaine (trimethylglycine, C5H11NO2) is a methyl donor that remethylates homocysteine to methionine, supporting methylation reactions. A narrative review of RCTs found improvements in body composition with exercise and homocysteine reduction. Safety concern: doses ≥4 g/day raise total and LDL cholesterol, potentially negating cardiovascular benefits. No effect on liver enzymes, triglycerides, or HDL. Used for homocysteine management, liver support (NASH/NAFLD), and athletic performance. Well tolerated at ≤3 g/day.
Dosage
500 mg · Any time · Can take on empty stomach
Key Interactions
18 verified interactions found
Taurine enhances betaine efficacy in homocysteine metabolism and enzyme function.
Taurin und Betain haben komplementäre Wirkungen auf Methylierung und Osmoprotektion. Kombination in Standarddosen ist unbedenklich; Gesamtzufuhr osmotisch aktiver Substanzen bei Nierenerkrankungen beachten.
View details →Cholin und Betain teilen gemeinsame Stoffwechselwege im Methylgruppen-Haushalt. Beide Substanzen erhöhen die intestinale TMA-Produktion, was TMAO-Spiegel und kardiovaskuläres Risiko beeinflussen kann.
Sowohl Cholin als auch Betain beeinflussen den Homocystein-Stoffwechsel; hohe Dosen beider Substanzen können sich addieren. Eine der beiden Substanzen ist für das Homocystein-Management ausreichend.
View details →Niacin supplementation reduces DNA methylation and uracil incorporation in developing fetal tissues, with betaine providing partial protection.
Hochdosiertes Nicotinamid kann Methylierungsreaktionen beeinflussen und dadurch die Betain-abhängige Homocystein-Remethylierung abschwächen. Bei therapeutischen Nicotinamid-Dosen (>500 mg/Tag) und gleichzeitiger Betain-Einnahme empfiehlt sich eine Kontrolle des Homocysteinspiegels.
View details →Betaine enhances meat quality markers more effectively than equivalent glycine doses.
Betain und Curcumin können sich in ihrer Wirkung auf den Stoffwechsel ergänzen; die Evidenz basiert auf Tierstudien. Eine Kombination beider Supplemente gilt als unbedenklich.
View details →Spraying glycine betaine on young tea plants regulates leaf development, increases beneficial compounds like theanine and caffeine, and reduces chlorophyll, suggesting altered leaf metabolism.
Die Wechselwirkung zwischen Betain und Theanin ist aus Pflanzenstudien beschrieben; eine direkte Relevanz für Humansupplemente ist nicht belegt. Eine gleichzeitige Einnahme gilt als unbedenklich.
View details →Scientific Sources
- Taurine alleviates repression of betaine‐homocysteine S‐methyltransferase and si (2019)
- Ultraviolet A induces transport of compatible organic osmolytes in human dermal (2008)
- Cytoprotection by the osmolytes βine and taurine in ischemia‐ reoxygenation inju (1997)
- Mixture suppression without inhibition for binary mixtures from whole cell patch (1995)
- Amino acid suppression of taurine-sensitive chemosensory neurons (1985)
- Choline and Betaine Intakes Are Not Associated with Cardiovascular Disease Morta (2015)
- Association of choline and betaine levels with cancer incidence and survival: A (2019)
- Choline and Betaine Intake and Colorectal Cancer Risk in Chinese Population: A C (2015)
- Choline and betaine intakes are associated with reduced risk of nasopharyngeal c (2014)
- Choline and betaine intake is inversely associated with breast cancer risk: A tw (2013)
- Maternal nicotinamide supplementation causes global DNA hypomethylation, uracil (2014)
- Nicotinamide supplementation induces detrimental metabolic and epigenetic change (2013)
- Co-administration of equimolar doses of betaine may alleviate the hepatotoxic ri (2000)
- Dietary supplementation with betaine or glycine improves the carcass trait, meat (2021)
- Improving Albino Tea Quality by Foliar Application of Glycinebetaine as a Green (2021)
- NIH Dietary Supplement Label Database (DSLD)
- PubChem Compound 247
Frequently Asked Questions
What is Betaine used for?
Betaine (trimethylglycine, C5H11NO2) is a methyl donor that remethylates homocysteine to methionine, supporting methylation reactions.
What is the recommended dosage for Betaine?
500 mg. Any time. Can take on empty stomach.
Does Betaine interact with other supplements?
Betaine has 18 verified interactions. Top: Taurine, Choline.
When is the best time to take Betaine?
Any time. Can take on empty stomach.
Is Betaine safe to combine with other supplements?
Always check interactions before combining supplements. Use VitalStack to verify your full stack for free.
Check how Betaine fits your full stack
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Check Your Stack →Not medical advice. VitalStack is not a medical device. For personalized health recommendations, consult a healthcare provider.