Cobalt
Overview
Cobalt (atomic no. 27) is an essential trace element relevant exclusively as the central Cobalt(III) atom in cobalamin (vitamin B12). No independent cobalt requirement exists — needs are met entirely via B12. Active forms: methylcobalamin, adenosylcobalamin (DNA synthesis, myelin, erythropoiesis, homocysteine metabolism). Free inorganic cobalt supplementation is NOT recommended — potentially toxic (cardiomyopathy, thyroid suppression, polycythemia). All cobalt supplementation must occur through cobalamin forms only. Risk groups: vegans, elderly, pernicious anemia. No EFSA upper limit for cobalt.
Dosage
0.1 mg · Any time · Can take on empty stomach
Key Interactions
15 verified interactions found
Higher serum selenium increases metabolic disease risk (opposite to cobalt pattern).
Hohe Selenspiegel in Kombination mit anderen Spurenelementen wurden mit metabolischen Veränderungen in Verbindung gebracht. Selen sollte nicht dauerhaft hochdosiert eingenommen werden; die EFSA empfiehlt maximal 300 µg/Tag für Erwachsene.
View details →Cobalt blocks calcium channels in heart muscle cells, reducing electrical activity and contraction force.
Cobalt-Ionen können Kalziumkanäle hemmen, die auch für leucinabhängige Signalmechanismen relevant sind. Eine klinisch bedeutsame Interaktion bei üblichen Supplementdosierungen ist nicht zu erwarten.
View details →Cobalt injection causes abnormal movement behavior, but effects are not related to piperin mechanisms.
Cobalt-Injektionen in die Substantia nigra zeigen dopaminerge Effekte; die klinische Relevanz für kombinierte Supplementierung ist nicht gesichert. Eine gleichzeitige Einnahme gilt als unbedenklich.
View details →Cobalt blocks neuronal responses to acidic amino acids including glutamate and aspartate.
Cobalt-Ionen können glutamatabhängige neuronale Übertragungswege beeinflussen. Eine klinisch relevante Interaktion bei üblichen Supplementdosierungen ist nicht bekannt.
View details →Cobalt ions interfere with calcium signaling in cells by blocking calcium channels, which can reduce the effects of certain drugs like nitrendipine that normally rely on calcium activation.
Kobalt-Ionen können laut präklinischer Daten bestimmte kalziumabhängige Signalwege hemmen. Eine gleichzeitige Einnahme mit Vitamin B6 ist unbedenklich.
View details →Scientific Sources
- High serum concentration of selenium, but not calcium, cobalt, copper, iron, and (2020)
- Specificity in Protection against Lethality and Testicular Toxicity from Cadmium (1968)
- SELENIUM TOXICITY IN DOMESTIC ANIMALS (1964)
- Cobalt as chemical modifier to improve chromium sensitivity and minimize matrix (2013)
- Simultaneous determination of arsenic, selenium, tin and mercury by non-dispersi (1985)
- T-type calcium current in latent pacemaker cells isolated from cat right atrium. (1994)
- Cobalt infections into the substantia nigra of the rat: Effects on behavior and (1978)
- Is histamine a neurotransmitter in insect photoreceptors? (2004)
- Cobalt blocks l-glutamate-induced apnea and arterial hypotension in the nucleus (1994)
- [3H]nitrendipine-labeled calcium channels discriminate inorganic calcium agonist (1982)
- NIH Dietary Supplement Label Database (DSLD)
- PubChem Compound 104730
Frequently Asked Questions
What is Cobalt used for?
Cobalt (atomic no.
What is the recommended dosage for Cobalt?
0.1 mg. Any time. Can take on empty stomach.
Does Cobalt interact with other supplements?
Cobalt has 15 verified interactions. Top: Selen, Leucine.
When is the best time to take Cobalt?
Any time. Can take on empty stomach.
Is Cobalt safe to combine with other supplements?
Always check interactions before combining supplements. Use VitalStack to verify your full stack for free.
Check how Cobalt fits your full stack
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Check Your Stack →Not medical advice. VitalStack is not a medical device. For personalized health recommendations, consult a healthcare provider.