Vitamin B6 (Pyridoxin)
Overview
Vitamin B6 (pyridoxine) is a water-soluble vitamin involved in over 100 enzyme reactions, mainly supporting protein metabolism, neurotransmitter synthesis, and immune function. Adults need 1.3–1.7 mg daily. The NIH sets the upper limit at 100 mg/day; EFSA uses a stricter 12 mg/day due to peripheral neuropathy risk. Chronic high-dose intake (1–6 g/day) has caused severe sensory nerve damage. Symptoms typically resolve after stopping supplementation.
Dosage
1.5 mg · Morning · Take with food
Key Interactions
12 verified interactions found
Cobalt ions interfere with calcium signaling in cells by blocking calcium channels, which can reduce the effects of certain drugs like nitrendipine that normally rely on calcium activation.
Kobalt-Ionen können laut präklinischer Daten bestimmte kalziumabhängige Signalwege hemmen. Eine gleichzeitige Einnahme mit Vitamin B6 ist unbedenklich.
View details →Riboflavin (as FMN) is needed for the conversion of pyridoxine to its active form pyridoxal-5-phosphate (PLP). B2 deficiency impairs B6 activation.
Ensure adequate B2 when supplementing B6. Best taken together as part of a B-complex.
View details →B6 and B12 cooperate in the homocysteine pathway and support nervous system function. Both are needed for proper methyl group metabolism and neurotransmitter synthesis.
Take together as part of a B-complex. Complementary roles in methylation and nerve health.
View details →Vitamins B6, B9 (folate), and B12 work together in the homocysteine metabolic pathway. B6 converts homocysteine to cysteine, while folate and B12 remethylate it to methionine.
Take together as part of a B-complex for optimal homocysteine metabolism and cardiovascular protection.
View details →Piperine's inhibition of glucuronidation and its enhancement of membrane permeability can modestly improve the absorption of B-vitamins including B6.
Can be taken together. Piperine may slightly enhance B6 bioavailability.
View details →Scientific Sources
- [3H]nitrendipine-labeled calcium channels discriminate inorganic calcium agonist (1982)
- Vitamin B2 + Vitamin B6 combination study (PMID:23829926)
- Vitamin B2 + Vitamin B6 combination study (PMID:28325140)
- Vitamin B2 + Vitamin B6 combination study (PMID:16018750)
- Vitamin B6 + Vitamin B12 combination study (PMID:32279306)
- Vitamin B6 + Vitamin B12 combination study (PMID:7762494)
- Vitamin B6 + Vitamin B12 combination study (PMID:10190392)
- Piperin + Vitamin B6 — no direct combination study found
- NIH Dietary Supplement Label Database (DSLD)
- PubChem Compound 1054
Frequently Asked Questions
What is Vitamin B6 (Pyridoxin) used for?
Vitamin B6 (pyridoxine) is a water-soluble vitamin involved in over 100 enzyme reactions, mainly supporting protein metabolism, neurotransmitter synthesis, and immune function.
What is the recommended dosage for Vitamin B6 (Pyridoxin)?
1.5 mg. Morning. Take with food.
Does Vitamin B6 (Pyridoxin) interact with other supplements?
Vitamin B6 (Pyridoxin) has 12 verified interactions. Top: Cobalt, Vitamin B2 (Riboflavin).
When is the best time to take Vitamin B6 (Pyridoxin)?
Morning. Take with food.
Is Vitamin B6 (Pyridoxin) safe to combine with other supplements?
Always check interactions before combining supplements. Use VitalStack to verify your full stack for free.
Check how Vitamin B6 (Pyridoxin) fits your full stack
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Check Your Stack →Not medical advice. VitalStack is not a medical device. For personalized health recommendations, consult a healthcare provider.