Glutamate
Overview
Glutamate (C5H9NO4) is the primary excitatory neurotransmitter (AMPA, NMDA, kainate receptors) and metabolic hub connecting TCA cycle, GABA synthesis, and ammonia detoxification. As monosodium glutamate (MSG), it is a widely used umami flavor enhancer. A comprehensive review found reported negative health effects of MSG have little relevance at typical human intake levels — the Chinese Restaurant Syndrome was not reproducible in double-blind studies. Supplementation in healthy individuals is not clinically indicated. Contraindicated in hepatic encephalopathy.
Dosage
500 mg · Any time · Can take on empty stomach
Key Interactions
17 verified interactions found
Glutamate and branched-chain amino acids together upregulate amino acid biosynthetic enzyme expression through overlapping signaling pathways.
Glutamat und verzweigtkettige Aminosäuren wie Valin teilen bestimmte Aminotransferase-Enzyme; eine gegenseitige Beeinflussung ist biochemisch plausibel. Eine gleichzeitige Einnahme gilt als unbedenklich.
View details →Cobalt blocks neuronal responses to acidic amino acids including glutamate and aspartate.
Cobalt-Ionen können glutamatabhängige neuronale Übertragungswege beeinflussen. Eine klinisch relevante Interaktion bei üblichen Supplementdosierungen ist nicht bekannt.
View details →Alpha-lipoic acid protects hippocampal neurons from glutamate-induced excitotoxicity.
Alpha-Liponsäure kann glutamatinduzierte neuronale Schäden in Zellmodellen reduzieren. Die klinische Relevanz dieser Schutzwirkung beim Menschen ist nicht gesichert; eine gleichzeitige Einnahme gilt als unbedenklich.
View details →Piperine and glutamate both elevate intracellular calcium, potentially enhancing neurotransmitter signaling in neuronal cells.
Piperin und Glutamat können über Kalzium-vermittelte intrazelluläre Signalwege interagieren; die klinische Relevanz ist begrenzt. Eine gleichzeitige Einnahme gilt als unbedenklich.
View details →Biotin deficiency triggers glutamate production, while pyruvate carboxylase activation by biotin increases lysine synthesis through metabolic reprogramming.
Biotin-Mangel kann laut präklinischer Daten die L-Glutamat-Produktion erhöhen. Eine ausreichende Biotin-Versorgung und eine gleichzeitige Glutamat-Einnahme sind unbedenklich.
View details →Scientific Sources
- Regulation of synthesis of glutamine synthetase in Escherichia coli. (1968)
- Is histamine a neurotransmitter in insect photoreceptors? (2004)
- Cobalt blocks l-glutamate-induced apnea and arterial hypotension in the nucleus (1994)
- Prolonged Pretreatment with α-Lipoic Acid Protects Cultured Neurons against Hypo (1995)
- Calcium alters the sensitivity of intact horizontal cells to dopamine antagonist (1982)
- Biotin protein ligase from Corynebacterium glutamicum: role for growth and l-lys (2011)
- NIH Dietary Supplement Label Database (DSLD)
- PubChem Compound 33032
Frequently Asked Questions
What is Glutamate used for?
Glutamate (C5H9NO4) is the primary excitatory neurotransmitter (AMPA, NMDA, kainate receptors) and metabolic hub connecting TCA cycle, GABA synthesis, and ammonia detoxification.
What is the recommended dosage for Glutamate?
500 mg. Any time. Can take on empty stomach.
Does Glutamate interact with other supplements?
Glutamate has 17 verified interactions. Top: Valine, Cobalt.
When is the best time to take Glutamate?
Any time. Can take on empty stomach.
Is Glutamate safe to combine with other supplements?
Always check interactions before combining supplements. Use VitalStack to verify your full stack for free.
Check how Glutamate fits your full stack
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Check Your Stack →Not medical advice. VitalStack is not a medical device. For personalized health recommendations, consult a healthcare provider.