Sulforaphan
Overview
Sulforaphane (C6H11NOS2) is an isothiocyanate from broccoli sprouts, formed when glucoraphanin is hydrolyzed by myrosinase. Key mechanism: Nrf2 transcription factor activation → phase II detoxification enzyme induction. A 2025 review confirms potential in cancer prevention, cardiovascular, diabetes, and neurological conditions; rigorous trials still needed. Bioavailability varies greatly: broccoli sprouts provide far more sulforaphane than supplements. Generally well tolerated; GI side effects possible. Caution during chemotherapy. Goitrogenic concerns at very high intake.
Dosage
20 mg · Empty stomach · Can take on empty stomach
Key Interactions
15 verified interactions found
Quercetin and sulforaphane together produce stronger anti-inflammatory and anti-cancer effects than either compound alone.
Quercetin und Sulforaphan zeigen in Zellstudien synergistische Wirkungen, insbesondere im Bereich des oxidativen Stressschutzes. Eine Kombination beider Supplemente gilt als sicher und gut verträglich.
View details →Piperine primarily inhibits Phase I CYP enzymes and UDP-glucuronosyltransferase, while sulforaphane activates Phase II detoxification via NRF2. The net effect of co-administration on sulforaphane efficacy is unclear due to lack of direct clinical studies.
Limited evidence for this specific combination. Consider separating intake by 2-4 hours if using both.
View details →EGCG and sulforaphane together produce synergistic anticancer effects, more potent than either alone.
EGCG und Sulforaphan zeigen synergistische zelluläre Effekte. Kombination in Standarddosen ist unkritisch; EGCG-Tagesmenge unter 800mg halten (EFSA 2018).
View details →Green tea and sulforaphane together reactivate estrogen receptor alpha, potentially offering novel approaches for hormone-sensitive cancers.
Grüntee-Polyphenole und Sulforaphan können beide als epigenetische Schutzsubstanzen wirken; eine Kombination kann diese Effekte verstärken. Eine gleichzeitige Einnahme gilt als sicher.
View details →Sulforaphane upregulates glutathione synthesis through NRF2 activation, and Vitamin C supports the glutathione recycling system. Both contribute to cellular antioxidant defense.
Can be taken together for complementary antioxidant support.
View details →Scientific Sources
- Dietary polyphenol quercetin targets pancreatic cancer stem cells. (2010)
- Sulforaphane synergizes with quercetin to inhibit self-renewal capacity of pancr (2011)
- Quercetin and sulforaphane in combination suppress the progression of melanoma t (2010)
- Source
- Combinatorial epigenetic mechanisms and efficacy of early breast cancer inhibiti (2016)
- Regulation of Nrf2- and AP-1-mediated gene expression by epigallocatechin-3-gall (2010)
- Combination of Epigallocatechin Gallate and Sulforaphane Counteracts In Vitro Ox (2018)
- Epigenetic reactivation of p21CIP1/WAF1 and KLOTHO by a combination of bioactive (2015)
- Sulforaphan + Vitamin C combination study (PMID:17995854)
- Sulforaphan + Vitamin C combination study (PMID:38870164)
- NIH Dietary Supplement Label Database (DSLD)
- PubChem Compound 5350
Frequently Asked Questions
What is Sulforaphan used for?
Sulforaphane (C6H11NOS2) is an isothiocyanate from broccoli sprouts, formed when glucoraphanin is hydrolyzed by myrosinase.
What is the recommended dosage for Sulforaphan?
20 mg. Empty stomach. Can take on empty stomach.
Does Sulforaphan interact with other supplements?
Sulforaphan has 15 verified interactions. Top: Quercetin, Piperin.
When is the best time to take Sulforaphan?
Empty stomach. Can take on empty stomach.
Is Sulforaphan safe to combine with other supplements?
Always check interactions before combining supplements. Use VitalStack to verify your full stack for free.
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Check Your Stack →Not medical advice. VitalStack is not a medical device. For personalized health recommendations, consult a healthcare provider.