Asparagine
Overview
Asparagine (C4H8N2O3) is a non-essential proteinogenic amino acid functioning as nitrogen shuttle, N-glycosylation initiator, and neurotransmitter precursor. Normally adequate via diet; no clinical benefit demonstrated for supplementation in healthy individuals. Key clinical context: certain cancers (acute lymphoblastic leukemia) are asparagine-auxotrophic and treated with L-asparaginase. Asparagine synthetase overexpression confers treatment resistance. No EFSA-authorized health claims. Supplementation in healthy populations is biochemically unnecessary.
Dosage
500 mg · Any time · Can take on empty stomach
Key Interactions
7 verified interactions found
Asparagine interacts with alpha-ketoglutarate to produce enzymatic activity that transfers amino groups between molecules.
Alpha-Ketoglutarat kann bestimmte Transaminierungsreaktionen von Asparagin beeinflussen. Die Interaktion ist biochemisch beschrieben; bei üblichen Supplementdosierungen ist keine klinisch relevante Wirkung zu erwarten.
View details →Daytime melatonin administration (but not nighttime dosing) reduces several amino acid levels in the blood, bringing them down to nighttime values, suggesting melatonin affects amino acid metabolism based on circadian timing.
Melatonin kann tagsüber eingenommen den Spiegel bestimmter Aminosäuren wie Asparagin beeinflussen. Eine gleichzeitige Einnahme beider Supplemente gilt als unbedenklich.
View details →Asparagine and aspartic acid reduce theanine's stress-relieving benefits.
Asparagin und Theanin können den Neurotransmitterhaushalt gemeinsam beeinflussen; die Evidenz ist begrenzt. Eine gleichzeitige Einnahme gilt als unbedenklich.
View details →Free asparagine is processed differently than linked forms due to enzyme limitations.
Kalium kann die enzymatische Hydrolyse von Asparagin in bestimmten Systemen beeinflussen. Eine klinisch relevante Wechselwirkung bei Supplementdosierungen ist nicht bekannt.
View details →Asparagine substitution dramatically reduces NAD+ and NADH binding efficiency in enzymes.
Bestimmte Aminosäuren wie Asparagin können die NAD+-Bindung an Enzymkomplexen beeinflussen. Eine klinisch relevante Wechselwirkung bei Supplementdosierungen ist nicht bekannt.
View details →Scientific Sources
- PubChem CID:6267
- L-asparaginase-mediated Therapy in L-asparagine Auxotrophic Cancers: A Review. (Anticancer Agents Med Chem, 2022)
- PubMed Batch-02
- PubMed Batch-02
- REGIONAL AND SUBCELLULAR DISTRIBUTION OF AMINOTRANSFERASES IN RAT BRAIN (1972)
- Glutamine and asparagine as nitrogen donors for reductant-dependent glutamate sy (1975)
- The Effects of Melatonin and L-DOPA on the Diurnal Rhythms of Free Amino Acids C (2000)
- Antidepressant Effect of Shaded White Leaf Tea Containing High Levels of Caffein (2020)
- Recombinant human glycosylasparaginase catalyzes hydrolysis of l‐asparagine (1997)
- Soil Potassium Deficiency Affects Soybean Phloem Nitrogen and Soybean Aphid Popu (2007)
- Substitutions of a buried glutamate residue hinder the conformational change in (2018)
- Active-site mutations of the diphtheria toxin catalytic domain: role of histidin (1994)
- NIH Dietary Supplement Label Database (DSLD)
- PubChem Compound 6267
Frequently Asked Questions
What is Asparagine used for?
Asparagine (C4H8N2O3) is a non-essential proteinogenic amino acid functioning as nitrogen shuttle, N-glycosylation initiator, and neurotransmitter precursor.
What is the recommended dosage for Asparagine?
500 mg. Any time. Can take on empty stomach.
Does Asparagine interact with other supplements?
Asparagine has 7 verified interactions. Top: Alpha-Ketoglutarate, Melatonin.
When is the best time to take Asparagine?
Any time. Can take on empty stomach.
Is Asparagine safe to combine with other supplements?
Always check interactions before combining supplements. Use VitalStack to verify your full stack for free.
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Check Your Stack →Not medical advice. VitalStack is not a medical device. For personalized health recommendations, consult a healthcare provider.