NAD+ (& Vorstufen NMN/NR)
Overview
NAD+ (C21H27N7O14P2) is a central coenzyme and substrate for sirtuins and PARP, declining with age. NMN and NR are preferred oral precursors. A systematic review confirmed oral NR/NMN increases NAD+ metabolites and is well tolerated over weeks to months. Animal models showed consistent metabolic benefits; human studies show inconsistent results with many null findings — clinical anti-aging efficacy remains inconclusive. Long-term safety data lacking. Preclinical concern: elevated NAD+ may support cancer cell energy metabolism — caution in active malignancy.
Dosage
250 mg · Any time · Can take on empty stomach
Key Interactions
25 verified interactions found
Niacin (B3 vitamin) increases NAD+ and NADH levels in pancreatic beta cells, boosting cellular energy and function.
Niacin (Nicotinamid) ist eine direkte Vorstufe von NAD+; kombinierte Einnahme mit NMN oder NR kann zu erhöhten NAD-Spiegeln führen. Nur eine Quelle für die NAD-Optimierung wählen und nicht beide gleichzeitig hochdosieren.
View details →Glutamine supplementation increases NAD and NADH levels, improving cellular energy.
Glutamin kann den NAD-Redox-Status signifikant erhöhen und die Wirkung von NAD-Vorstufen verstärken. Kombination ist bei gezielter NAD-Optimierung sinnvoll; Gesamt-Tagesdosen im empfohlenen Bereich halten.
View details →Melatonin enhances NAD+ levels by inhibiting NADase, the enzyme that degrades NAD+ to ADP-ribose and nicotinamide.
Melatonin kann den NAD+-Spiegel in Zellen erhöhen und so die mitochondriale Funktion unterstützen. Eine Kombination beider Supplemente ist grundsätzlich möglich; hochdosierte Einnahmen sollten ärztlich begleitet werden.
View details →Low-dose NAD+ precursors work together with leucine to increase SIRT1 enzyme activity significantly, reducing atherosclerotic plaques and improving overall metabolic health in mice.
Leucin und NAD+-Vorstufen (NMN/NR) wirken synergistisch bei der Sirt1-Aktivierung. Kombination in Standarddosen ist unkritisch; nicht beide gleichzeitig hochdosieren.
View details →Resveratrol activates the longevity protein SIRT1 by increasing NAD+ levels via the salvage pathway.
Resveratrol aktiviert SIRT1 und erhöht die NAD+-Verfügbarkeit; eine Kombination mit NMN/NR kann diese Wirkung verstärken. Die gleichzeitige Einnahme gilt als sicher und wird in der Longevity-Forschung aktiv untersucht.
View details →What Experts Say
“"I don't personally believe there is enough evidence to think that NAD precursors as they are being marketed today are likely to benefit most people. There's at least one study in mice that giving NMN to aged mice causes kidney inflammation."”
The roundtable panel debates oral NAD precursors (NMN, NR). Key concern: when taken orally, all precursors get broken down to niacin in the gut — raising the question of why consumers pay $70+. Peter calls NAD "a very interesting molecule" but the panel (Dr. Matt Kaeberlein) concludes: no meaningful evidence that oral precursors benefit most healthy people. Safety flag: one mouse study showed NMN causes kidney inflammation in aged mice.
Scientific Sources
- Source
- Source
- Nicotinamide Effects Oxidative Burst Activity of Neutrophils in Patients with Po (2004)
- NAD+ homeostasis in renal health and disease (2019)
- Glaucoma as a Metabolic Optic Neuropathy: Making the Case for Nicotinamide Treat (2017)
- Dependence of tumor cell lines and patient-derived tumors on the NAD salvage pat (2013)
- Supplementation of nicotinic acid with NAMPT inhibitors results in loss of in vi (2013)
- Oral L‐glutamine therapy for sickle cell anemia: I. subjective clinical improvem (1998)
- Nicotinamide adenine dinucleotide induces a bivalent metabolism and maintains pl (2020)
- Estradiol stimulates the biosynthetic pathways of breast cancer cells: detection (2006)
- Proper positioning of the nicotinamide ring is crucial for the Ascaris suum mali (2008)
- L-[alphaS, 5S]-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (NSC-1635 (1975)
- A role for NAD+ and cADP-ribose in melatonin signal transduction (1998)
- Melatonin regulates mitochondrial function and biogenesis during rat dental papi (2019)
- Melatonin inhibits Sirt1-dependent NAMPT and NFAT5 signaling in chondrocytes to (2017)
- Modulation of Energy Sensing by Leucine Synergy with Natural Sirtuin Activators: (2020)
- Synergistic Effects of Polyphenols and Methylxanthines with Leucine on AMPK/Sirt (2014)
- Vitamin B6 nutritional status of pellagrins and their leucine tolerance. (1978)
- Leucine dehydrogenase from Bacillus stearothermophilus: identification of active (1992)
- Resveratrol-Induced AMP-Activated Protein Kinase Activation Is Cell-Type Depende (2017)
- Resveratrol Induces a Mitochondrial Complex I-dependent Increase in NADH Oxidati (2013)
- Sirtuins in cognitive ageing and Alzheimer's disease (2012)
- Resveratrol ameliorates hepatic metaflammation and inhibits NLRP3 inflammasome a (2014)
- Zinc neurotoxicity is dependent on intracellular NAD+ levels and the sirtuin pat (2006)
- NIH Dietary Supplement Label Database (DSLD)
- PubChem Compound 5892
Frequently Asked Questions
What is NAD+ (& Vorstufen NMN/NR) used for?
NAD+ (C21H27N7O14P2) is a central coenzyme and substrate for sirtuins and PARP, declining with age.
What is the recommended dosage for NAD+ (& Vorstufen NMN/NR)?
250 mg. Any time. Can take on empty stomach.
Does NAD+ (& Vorstufen NMN/NR) interact with other supplements?
NAD+ (& Vorstufen NMN/NR) has 25 verified interactions. Top: Vitamin B3 (Niacin), Glutamine.
When is the best time to take NAD+ (& Vorstufen NMN/NR)?
Any time. Can take on empty stomach.
Is NAD+ (& Vorstufen NMN/NR) safe to combine with other supplements?
Always check interactions before combining supplements. Use VitalStack to verify your full stack for free.
Check how NAD+ (& Vorstufen NMN/NR) fits your full stack
Verify interactions, get timing plans, and optimize your supplement routine — free.
Check Your Stack →Not medical advice. VitalStack is not a medical device. For personalized health recommendations, consult a healthcare provider.