L-Carnitin
Overview
L-carnitine is a quaternary ammonium compound (C7H15NO3) synthesized from lysine and methionine, essential for transporting long-chain fatty acids into mitochondria for beta-oxidation. Used for cardiovascular support, exercise performance, and cognitive function. A 2024 review raised safety concerns: gut microbiota convert L-carnitine to TMAO, linked to atherosclerosis risk. Generally well tolerated at standard doses; GI side effects at higher doses. Safety at high doses "remains an issue for scientific investigation."
Dosage
2000 mg · Morning · Take with food
Key Interactions
19 verified interactions found
L-Carnitin und Acetylcarnitin beeinflussen gegenseitig ihre renale Ausscheidung. Bei kombinierter Einnahme können Plasmaspiegel beider Carnitin-Formen verändert sein.
L-Carnitin und Acetyl-L-Carnitin werden über dieselben renalen Transporter ausgeschieden und können sich gegenseitig beeinflussen. Eine der beiden Formen wählen oder Gesamtdosis auf ≤2g/Tag begrenzen.
View details →Ascorbate is a cofactor for two hydroxylase reactions in L-carnitine biosynthesis (epsilon-N-trimethyllysine hydroxylase and gamma-butyrobetaine hydroxylase). While biochemically required, recent knockout mouse studies suggest in vivo compensatory mechanisms may exist. Clinical deficiency of Vitamin C does correlate with reduced carnitine levels and fatigue.
Ensure adequate Vitamin C intake for optimal L-carnitine synthesis. Particularly important for vegetarians and vegans who have lower carnitine intake.
View details →L-carnitine and CoQ10 together improve sexual hormone levels and semen quality, indicating enhanced mitochondrial energy production and antioxidant protection.
L-Carnitin und CoQ10 zeigen synergistische Effekte auf Energiestoffwechsel und Spermienparameter. Kombination in Standarddosen (Carnitin ≤2g, CoQ10 ≤100mg) ist unkritisch und kann sinnvoll sein.
View details →L-carnitine and vitamin E together enhance fat utilization and improve blood lipid profiles.
L-Carnitin kann den Vitamin-E-Status verbessern und die Fettverbrennung unterstützen. Kombination in Standarddosen ist unkritisch.
View details →Creatine supports the phosphocreatine energy system for short-burst activity while L-carnitine supports fatty acid oxidation for sustained energy. They address complementary energy pathways.
Can be taken together. Complementary energy metabolism support for athletic performance.
View details →Scientific Sources
- PubChem CID:10917
- Role of L-carnitine in Cardiovascular Health: Literature Review. (Cureus, 2024 Sep)
- Pharmacokinetics of propionyl-L-carnitine in humans: evidence for saturable tubu (2000)
- Metabolic changes induced by maximal exercise in human subjects following L-carn (1990)
- Comparison of pharmacokinetics of L-carnitine, acetyl-L-carnitine and propionyl- (2009)
- Changes in the levels of l-carnitine, acetyl-l-carnitine and propionyl-l-carniti (2016)
- Neuroprotective Effects of Pre-Treament with l-Carnitine and Acetyl-l-Carnitine (2012)
- Vitamin C + L-carnitine biosynthesis (2023)
- Ascorbic acid + carnitine combination (2020)
- Vitamin C L-carnitine synthesis review (2020)
- CoQ10 and L-carnitine attenuate the effect of high LDL and oxidized LDL on sperm (2014)
- Effects of L-carnitine and coenzyme q10 on impaired spermatogenesis caused by is (2014)
- Effects of dietary L-carnitine and coenzyme Q10 at different supplemental ages o (2007)
- Fumonisin B1-induced DNA damage in rat liver and spleen: effects of pretreatment (1999)
- Protective action of L-carnitine and coenzyme Q10 against hepatic triglyceride i (1993)
- L-carnitine increases liver alpha-tocopherol and lowers liver and plasma triglyc (2007)
- Neuroprotective effects of L-carnitine and vitamin E alone or in combination aga (2006)
- Dietary L-carnitine enhances the lymphatic absorption of fat and alpha-tocophero (2005)
- Comparison of Vitamin E and L-Carnitine, Separately or in Combination in Patient (2013)
- The Influence of L-Carnitine on Oxidative Modification of LDL In Vitro (2008)
- Creatine + L-carnitine combination (2022)
- Creatine + carnitine energy metabolism (2020)
- Creatine + L-carnitine muscle performance (2022)
- NIH Dietary Supplement Label Database (DSLD)
- PubChem Compound 10917
Frequently Asked Questions
What is L-Carnitin used for?
L-carnitine is a quaternary ammonium compound (C7H15NO3) synthesized from lysine and methionine, essential for transporting long-chain fatty acids into mitochondria for beta-oxidation.
What is the recommended dosage for L-Carnitin?
2000 mg. Morning. Take with food.
Does L-Carnitin interact with other supplements?
L-Carnitin has 19 verified interactions. Top: Acetylcarnitine, Vitamin C (Ascorbic Acid).
When is the best time to take L-Carnitin?
Morning. Take with food.
Is L-Carnitin safe to combine with other supplements?
Always check interactions before combining supplements. Use VitalStack to verify your full stack for free.
Check how L-Carnitin fits your full stack
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