Plant Sterols

Metabolic Evidence: strong

Overview

Plant sterols/stanols (β-sitosterol dominant, CID 222284; also campesterol, stigmasterol) are structurally similar to cholesterol and competitively inhibit intestinal cholesterol absorption via ABCG5/ABCG8 transporter competition. Doses of 2–3 g/day produce consistent LDL reductions of 6–15% across 28+ RCTs — evidence level is strong. Endorsed by EAS and ACC/AHA guidelines for dyslipidemia management. IMPORTANT INTERACTIONS: reduce absorption of fat-soluble vitamins A, D, E, K — supplementation of fat-soluble vitamins recommended with long-term use; additive LDL-lowering with statins (safe combination); may reduce absorption of lipophilic drugs (cyclosporine, digoxin) — take 2h apart. Individual response influenced by ABCG8/ABO genetic variants.

Dosage

2000 mg · With meal · Take with food

Key Interactions

1 verified interaction found

Phosphatidylserin Info

Plant sterols enhance membrane structure when combined with phospholipids

May work synergistically with phospholipid supplements for membrane health

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Scientific Sources

Frequently Asked Questions

What is Plant Sterols used for?

What is the recommended dosage for Plant Sterols?

2000 mg. With meal. Take with food.

Does Plant Sterols interact with other supplements?

Plant Sterols has 1 verified interactions. Top: Phosphatidylserin.

When is the best time to take Plant Sterols?

With meal. Take with food.

Is Plant Sterols safe to combine with other supplements?

Always check interactions before combining supplements. Use VitalStack to verify your full stack for free.

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Not medical advice. VitalStack is not a medical device. For personalized health recommendations, consult a healthcare provider.