Proline
Overview
Proline (C5H9NO2) is a non-essential cyclic imino acid constituting ~25% of collagen amino acids (together with hydroxyproline). Vitamin C-dependent hydroxylation by prolyl-4-hydroxylase is essential for collagen triple-helix stability. A critical review found biochemical barriers in enteral metabolism limit supplementation effectiveness for wound healing. Vitamin C co-supplementation is essential for proline utilization. No isolated proline RCT evidence; proline is best delivered as part of collagen hydrolysate. No EFSA-authorized health claims for isolated proline.
Dosage
500 mg · Any time · Can take on empty stomach
Key Interactions
19 verified interactions found
Sarcosine and proline reduce maximum blood levels of taurine by competing for absorption.
Prolin kann die Taurinaufnahme durch Transportkonkurrenz am Darm beeinflussen. Für eine optimale Taurin-Resorption empfiehlt sich eine zeitlich versetzte Einnahme (mind. 1–2 Stunden Abstand).
View details →Alpha-ketoglutarate increases proline levels in the blood while reducing other amino acids like taurine and glutamine, suggesting it enhances proline availability and metabolism.
Alpha-Ketoglutarat kann Prolin-Plasmaspiegel erhöhen. Kombination bei ausgewogener Aminosäurezufuhr unkritisch; Gesamt-Aminosäurezufuhr im Blick behalten.
View details →Glycine blocks proline uptake, preventing embryonic stem cell differentiation in response to growth signals.
Glycin kann die zelluläre Prolin-Aufnahme hemmen. Bei gleichzeitiger Supplementierung beider Aminosäuren zeitversetzt einnehmen (mindestens 2h Abstand).
View details →Vitamin E and vitamin C together prevent harmful nitrosation of proline amino acids.
Vitamin E hemmt die Nitrosierung von Prolin im Körper und kann so die Bildung von N-Nitrosoverbindungen reduzieren. Die Kombination beider Supplemente gilt als sicher; eine besondere Dosisanpassung ist nicht erforderlich.
View details →Optimal magnesium, vitamin K, and vitamin D intake prevents phosphate-driven vascular calcification and excessive parathyroid hormone elevation.
Vitamin K kann laut präklinischer Daten zusammen mit Prolin und Magnesium vaskuläre Verkalkung durch Phosphat entgegenwirken. Eine gemeinsame Einnahme ist unbedenklich.
View details →Scientific Sources
- Source
- Oral and intravenous pharmacokinetics of taurine in sprague‐dawley rats: the inf (2017)
- Effects of Taurine Supplementation on Growth in Low Birth Weight Infants: A Syst (2018)
- Renal transport of taurine in luminal membrane vesicles from rabbit proximal tub (1991)
- FREE AMINO ACIDS IN DEVELOPING RAT RETINA (1974)
- Effects of alpha-ketoglutarate on bone homeostasis and plasma amino acids in tur (2005)
- Efficient production of trans‐4‐Hydroxy‐l‐proline from glucose by metabolic engi (2018)
- Alpha-ketoglutarate enhances freeze–thaw tolerance and prevents carbohydrate-ind (2017)
- L-Proline induces differentiation of ES cells: a novel role for an amino acid in (2010)
- Placental transport of leucine, phenylalanine, glycine, and proline in intrauter (2001)
- Development of novel CXC chemokine receptor 7 (CXCR7) ligands: selectivity switc (2015)
- Hyperconjugation Contributes to the Bimodal Distribution of Glycine Conformation (2011)
- [Synthesis of N-alpha-(arylsulfonyl-L-prolyl)- and N alpha-(benzyloxycarbonyl-L- (1986)
- Quantitative estimation of endogenous nitrosation in humans by monitoring N-nitr (1981)
- Hyperprolinemia induces DNA, protein and lipid damage in blood of rats: antioxid (2014)
- α-Tocopherol and ascorbic acid prevent memory deficits provoked by chronic hyper (2006)
- Bioavailable dietary phosphate, a mediator of cardiovascular disease, may be dec (2014)
- NIH Dietary Supplement Label Database (DSLD)
- PubChem Compound 145742
Frequently Asked Questions
What is Proline used for?
Proline (C5H9NO2) is a non-essential cyclic imino acid constituting ~25% of collagen amino acids (together with hydroxyproline).
What is the recommended dosage for Proline?
500 mg. Any time. Can take on empty stomach.
Does Proline interact with other supplements?
Proline has 19 verified interactions. Top: Taurine, Alpha-Ketoglutarate.
When is the best time to take Proline?
Any time. Can take on empty stomach.
Is Proline safe to combine with other supplements?
Always check interactions before combining supplements. Use VitalStack to verify your full stack for free.
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Check Your Stack →Not medical advice. VitalStack is not a medical device. For personalized health recommendations, consult a healthcare provider.