Serine
Overview
Serine (C3H7NO3) is a non-essential hydroxyl amino acid essential for phospholipid and sphingolipid synthesis, glutathione production, and NMDA receptor co-agonist D-serine production. A Phase I clinical trial found L-serine supplementation (up to 15 g/day) produced a dose-related ~34% decrease in ALS progression rate, hypothesized to buffer against environmental neurotoxin BMAA. Safety confirmed at high doses. Investigational for neurodegenerative conditions. No EFSA-authorized health claims. Generally adequate via dietary protein.
Dosage
500 mg · Any time · Can take on empty stomach
Key Interactions
14 verified interactions found
Berberine suppresses serine phosphorylation of insulin signaling proteins, enhancing glucose uptake through improved tyrosine phosphorylation.
Berberin kann laut präklinischer Daten die Serin-Phosphorylierung des Insulinrezeptorsubstrats hemmen. Eine gleichzeitige Einnahme ist unbedenklich; klinische Relevanz ist nicht belegt.
View details →Manganese decreases serine phosphorylation of Huntingtin protein in neurons.
Übermäßige Mangan-Exposition kann die Serin-Phosphorylierung in Neuronen verringern; die Relevanz bei Supplementdosierungen ist nicht bekannt. Eine gleichzeitige Einnahme gilt als unbedenklich.
View details →Sulforaphane reduces hyperglycemia-induced oxidative stress and suppresses AKT signaling, protecting cells from diabetes-related damage.
Sulforaphan kann laut präklinischer Daten bestimmte Serin-Phosphorylierungswege hemmen, was die zelluläre Signalgebung beeinflusst. Eine gleichzeitige Einnahme ist unbedenklich.
View details →Mutations replacing key amino acids with serine and phenylalanine in vitamin K epoxide reductase significantly reduce its enzymatic activity, affecting blood clotting and bone metabolism.
Vitamin-K2-abhängige Proteine nutzen Serin-Reste für ihre Bindung; Serin kann diese Wechselwirkung modulieren. Eine gleichzeitige Einnahme in üblichen Dosierungen gilt als unbedenklich.
View details →Thiamine (B1) enables serine incorporation into proteins, playing a critical role in protein synthesis when the vitamin is deficient.
Thiamin kann laut präklinischer Daten den Einbau von Serin in Proteine verbessern. Eine gleichzeitige Einnahme ist unbedenklich.
View details →Scientific Sources
- Nandinine, a Derivative of Berberine, Inhibits Inflammation and Reduces Insulin (2017)
- BDNF and Huntingtin protein modifications by manganese: implications for striata (2014)
- Nrf2-Heme Oxygenase-1 Attenuates High-Glucose-Induced Epithelial-to-Mesenchymal (2019)
- Identification of Sequences within the γ-Carboxylase That Represent a Novel Cont (2001)
- Mechanism of inhibition of aldose reductase by menadione (vitamin K3). (1992)
- Influence of thiamine on protein biosynthesis. (1969)
- NIH Dietary Supplement Label Database (DSLD)
- PubChem Compound 5951
Frequently Asked Questions
What is Serine used for?
Serine (C3H7NO3) is a non-essential hydroxyl amino acid essential for phospholipid and sphingolipid synthesis, glutathione production, and NMDA receptor co-agonist D-serine production.
What is the recommended dosage for Serine?
500 mg. Any time. Can take on empty stomach.
Does Serine interact with other supplements?
Serine has 14 verified interactions. Top: Berberine, Manganese.
When is the best time to take Serine?
Any time. Can take on empty stomach.
Is Serine safe to combine with other supplements?
Always check interactions before combining supplements. Use VitalStack to verify your full stack for free.
Check how Serine fits your full stack
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Check Your Stack →Not medical advice. VitalStack is not a medical device. For personalized health recommendations, consult a healthcare provider.