Threonine
Overview
Threonine (C4H9NO3) is an essential hydroxyl amino acid critical for gut mucosal barrier integrity — it is the most abundant amino acid in intestinal mucins. A review confirmed threonine as essential for intestinal mucosal mass maintenance, mucin synthesis, and immune glycoprotein production. It is typically the first limiting amino acid in plant-based proteins. Serves as phosphorylation site in signal transduction. No RCT evidence for supplementation in healthy individuals; important to ensure adequate intake on plant-based diets.
Dosage
500 mg · Any time · Can take on empty stomach
Key Interactions
15 verified interactions found
Threonine supplementation increases spinal cord glycine levels, potentially treating muscle spasticity.
Threonin kann Glycin-Spiegel erhöhen; kombinierte Einnahme beeinflusst den Glycin-Stoffwechsel. Kombination in Standarddosen ist unkritisch.
View details →Threonine intake affects how the body retains or utilizes leucine.
Threonin-Zufuhr beeinflusst Leucin-Bilanzen im Aminosäurestoffwechsel. Kombination in Standarddosen ist unkritisch; ausgewogene BCAA-Zufuhr sicherstellen.
View details →High threonine increases brain amino acid levels (histidine and lysine) while reducing branched-chain amino acid imbalance.
Threonin-Zufuhr beeinflusst Histidin-Konzentration im Aminosäurestoffwechsel. Kombination in Standarddosen ist unkritisch; ausgewogene Aminosäurezufuhr sicherstellen.
View details →Glutamine supplementation increases plasma threonine and other amino acid levels significantly.
Glutamin-Supplementierung kann Threonin-Plasmaspiegel erhöhen. Kombination in Standarddosen ist unkritisch; Gesamt-Aminosäurezufuhr beachten.
View details →Thiamine and threonine together, when added with related amino acids, significantly increase antibody production in cell cultures, enhancing the immune response.
Threonin in Kombination mit Thiamin kann laut präklinischer Daten die Produktion bioaktiver Verbindungen steigern. Eine gemeinsame Einnahme ist unbedenklich.
View details →Scientific Sources
- L‐Threonine in the Treatment of Spasticity (1991)
- Effect of Increasing Dietary Threonine Intakes on Amino Acid Metabolism of the C (1998)
- Threonine dehydrogenase is a minor degradative pathway of threonine catabolism i (2000)
- [Serum levels of various free amino acids in patients with collagen pneumoconios (1990)
- Supplemental glycine and threonine effects on performance, intestinal mucosa dev (2013)
- Threonine requirements of healthy Indian men, measured by a 24-h indicator amino (2002)
- Molecular evolution of the switch for progesterone and spironolactone from miner (2019)
- Effects of flooding amino acids on incorporation of labeled amino acids into hum (1998)
- Effect of leucine on amino acid and glucose metabolism in humans. (1992)
- Comparison between intravenous lidocaine and fentanyl on cough reflex and sympat (2020)
- Maintenance threonine requirement and efficiency of its use for accretion of who (2006)
- Maintenance threonine requirement and efficiency of its use for accretion of who (1997)
- The optimal amino acid supplementation of barley for the growing pig. 1. Respons (1979)
- Amino Acid Uptake into Cultivated Mesophyll Cells from Asparagus officinalis L. (1979)
- Dietary glutamine affects mucosal functions in rats with mild DSS-induced coliti (2007)
- Cultivation of Recombinant Baby Hamster Kidney Cells in a Fluidized Bed Bioreact (1994)
- Glutamine force-feeding effect on plasma amino-acid concentrations in growing ra (1994)
- Implication of Fusarium graminearum primary metabolism in its resistance to benz (2018)
- Transient responses of hybridoma cells in continuous culture to step changes in (1994)
- NIH Dietary Supplement Label Database (DSLD)
- PubChem Compound 6288
Frequently Asked Questions
What is Threonine used for?
Threonine (C4H9NO3) is an essential hydroxyl amino acid critical for gut mucosal barrier integrity — it is the most abundant amino acid in intestinal mucins.
What is the recommended dosage for Threonine?
500 mg. Any time. Can take on empty stomach.
Does Threonine interact with other supplements?
Threonine has 15 verified interactions. Top: Glycine, Leucine.
When is the best time to take Threonine?
Any time. Can take on empty stomach.
Is Threonine safe to combine with other supplements?
Always check interactions before combining supplements. Use VitalStack to verify your full stack for free.
Check how Threonine fits your full stack
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Check Your Stack →Not medical advice. VitalStack is not a medical device. For personalized health recommendations, consult a healthcare provider.