Maca
Overview
Maca (Lepidium meyenii) is a Peruvian root vegetable with 17 color phenotypes; yellow, black, and red are most studied. Active compounds include macamides (unique fatty acid amides) and glucosinolates. Used for energy, fertility, and sexual function. A 2024 systematic review identified significant research standardization gaps. Generally well tolerated. May be mildly thyroid-active (goitrogenic glucosinolates); caution in thyroid disorders. No established upper limit. Lacks the clinical evidence base of well-characterized botanical extracts.
Dosage
2000 mg · Morning · Take with food
Key Interactions
4 verified interactions found
Maca supports energy and libido via hypothalamic-pituitary axis modulation; Ashwagandha reduces cortisol and supports testosterone. Complementary adaptogenic and hormonal support.
Combine for energy, libido, and stress resilience.
View details →Both support hormonal health through different mechanisms. Maca modulates the hypothalamic-pituitary axis; Tribulus supports luteinizing hormone signaling.
Combine for hormonal and vitality support.
View details →Maca supports reproductive health; Zinc is essential for testosterone and sperm quality.
Combine for male vitality.
View details →Maca supports energy and hormonal balance; Vitamin D3 supports testosterone and overall hormonal health via VDR.
Combine for hormonal support.
View details →Scientific Sources
- Maca (Lepidium meyenii Walp.) as a potential agent for the management of anemia (Nutrients, 2024 Feb 7)
- pubmed_ncbi_api
- pubmed_ncbi_api
- Adaptogens interactions retrospective chart review (2023)
- Phytotherapics on testosterone — Maca + Ashwagandha (2019)
- Adaptogen combination hormonal review (2024)
- Maca + Tribulus combination study (PMID:27784600)
- Maca + Tribulus combination study (PMID:26531010)
- Maca + Tribulus combination study (PMID:22575847)
- Maca + Vitamin D3 combination study (PMID:31798745)
- Maca + Vitamin D3 combination study (PMID:36959959)
- Maca + Vitamin D3 combination study (PMID:25668332)
- NIH Dietary Supplement Label Database (DSLD)
Frequently Asked Questions
What is Maca used for?
Maca (Lepidium meyenii) is a Peruvian root vegetable with 17 color phenotypes; yellow, black, and red are most studied.
What is the recommended dosage for Maca?
2000 mg. Morning. Take with food.
Does Maca interact with other supplements?
Maca has 4 verified interactions. Top: Ashwagandha (KSM-66), Tribulus terrestris.
When is the best time to take Maca?
Morning. Take with food.
Is Maca safe to combine with other supplements?
Always check interactions before combining supplements. Use VitalStack to verify your full stack for free.
Check how Maca fits your full stack
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Check Your Stack →Not medical advice. VitalStack is not a medical device. For personalized health recommendations, consult a healthcare provider.