MSM (Methylsulfonylmethan)
Overview
MSM (dimethylsulfone, C2H6O2S) is an organosulfur compound providing bioavailable sulfur for collagen, keratin, and glutathione synthesis. Anti-inflammatory via NF-κB inhibition. A network meta-analysis of 23 RCTs ranked MSM second for WOMAC pain reduction in osteoarthritis (SUCRA 89%), though overall evidence quality was low (GRADE). Generally well tolerated; occasional GI upset. Often combined with glucosamine and chondroitin. No established upper limit.
Dosage
3000 mg · Any time · Take with food
Key Interactions
4 verified interactions found
Hyaluronic Acid provides joint lubrication and skin hydration; MSM supplies sulfur for connective tissue formation. Complementary joint support mechanisms.
Combine for joint comfort and mobility.
View details →MSM provides sulfur for glycosaminoglycan synthesis; Chondroitin is itself a glycosaminoglycan that supports cartilage hydration and resilience. Additive joint support.
Combine for joint health. Often used together in joint formulas.
View details →Boswellia reduces inflammatory mediators (leukotrienes); MSM provides sulfur for connective tissue repair and reduces oxidative stress in joints.
Combine for joint health and inflammation management.
View details →Collagen provides amino acid building blocks (glycine, proline, hydroxyproline); MSM provides bioavailable sulfur needed for keratin and connective tissue cross-linking.
Combine for comprehensive joint and connective tissue support.
View details →Scientific Sources
- PubChem CID:6107
- Effects of dietary supplements on patients with osteoarthritis: A systematic review and ne... (J Integr Med, 2025 Jul)
- pubmed_ncbi_api
- pubmed_ncbi_api
- Hyaluronsäure + MSM combination study (PMID:38316633)
- Hyaluronsäure + MSM combination study (PMID:33685850)
- Hyaluronsäure + MSM combination study (PMID:40561485)
- MSM + Chondroitin combination study (PMID:28790224)
- MSM + Chondroitin combination study (PMID:26978418)
- Boswellia + MSM (PMID:38785054)
- Boswellia + MSM (PMID:31608447)
- Boswellia + MSM (PMID:33617972)
- Kollagen + MSM combination study (PMID:26550817)
Frequently Asked Questions
What is MSM (Methylsulfonylmethan) used for?
MSM (dimethylsulfone, C2H6O2S) is an organosulfur compound providing bioavailable sulfur for collagen, keratin, and glutathione synthesis.
What is the recommended dosage for MSM (Methylsulfonylmethan)?
3000 mg. Any time. Take with food.
Does MSM (Methylsulfonylmethan) interact with other supplements?
MSM (Methylsulfonylmethan) has 4 verified interactions. Top: Hyaluronsäure (Hyaluronic Acid), Chondroitin.
When is the best time to take MSM (Methylsulfonylmethan)?
Any time. Take with food.
Is MSM (Methylsulfonylmethan) safe to combine with other supplements?
Always check interactions before combining supplements. Use VitalStack to verify your full stack for free.
Check how MSM (Methylsulfonylmethan) fits your full stack
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Check Your Stack →Not medical advice. VitalStack is not a medical device. For personalized health recommendations, consult a healthcare provider.