Pine Bark Extract (Pycnogenol)
Overview
Pycnogenol® is a standardized extract from French maritime pine bark (Pinus pinaster) containing 70% procyanidins (OPCs), catechins, taxifolin, and phenolic acids. Inhibits NF-κB-mediated inflammation, enhances nitric oxide synthesis (eNOS upregulation), and scavenges free radicals. Mechanistic evidence is strong; however, a 2012 Cochrane review (15 RCTs, 791 participants) concluded evidence remains insufficient for treating any specific chronic condition due to small sample sizes and heterogeneity. Emerging evidence for endothelial function, ADHD in children, and osteoarthritis. At 150–300 mg/day, well-tolerated with minimal adverse events. INTERACTIONS: theoretical additive antiplatelet effects with warfarin/aspirin — caution; may potentiate antihypertensives. No major drug-drug interactions documented.
Dosage
150 mg · With meal · Take with food
Key Interactions
3 verified interactions found
Pycnogenol protects DHA from oxidation and supports circulation; DHA supports cardiovascular health via triglyceride reduction.
Combine for cardiovascular protection.
View details →Pycnogenol supports endothelial NO production; CoQ10 supports cardiac mitochondrial energy. Complementary cardiovascular support.
Combine for heart health.
View details →Pycnogenol enhances and stabilizes Vitamin C. Both support collagen and vascular endothelial function.
Combine for skin and vascular health.
View details →Scientific Sources
- Source
- Source
- Pycnogenol + DHA omega-3 combination study (PMID:38757126)
- Pycnogenol + DHA omega-3 combination study (PMID:22513958)
- Pycnogenol + DHA omega-3 combination study (PMID:28836883)
- Pycnogenol + Vitamin C combination study (PMID:11996210)
- Pycnogenol + Vitamin C combination study (PMID:12525796)
- Pycnogenol + Vitamin C combination study (PMID:14990359)
Frequently Asked Questions
What is Pine Bark Extract (Pycnogenol) used for?
Pycnogenol® is a standardized extract from French maritime pine bark (Pinus pinaster) containing 70% procyanidins (OPCs), catechins, taxifolin, and phenolic acids.
What is the recommended dosage for Pine Bark Extract (Pycnogenol)?
150 mg. With meal. Take with food.
Does Pine Bark Extract (Pycnogenol) interact with other supplements?
Pine Bark Extract (Pycnogenol) has 3 verified interactions. Top: DHA (Omega-3), Ubiquinone.
When is the best time to take Pine Bark Extract (Pycnogenol)?
With meal. Take with food.
Is Pine Bark Extract (Pycnogenol) safe to combine with other supplements?
Always check interactions before combining supplements. Use VitalStack to verify your full stack for free.
Check how Pine Bark Extract (Pycnogenol) fits your full stack
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Check Your Stack →Not medical advice. VitalStack is not a medical device. For personalized health recommendations, consult a healthcare provider.