Ginkgo biloba
Overview
Ginkgo biloba leaf extract (EGb761: 24% flavonoids, 6% terpenoids) has been studied for cognitive decline and dementia. A 2015 meta-analysis of 9 RCTs (n=2,561) found EGb761 at 240 mg/day stabilizes cognitive decline and improves neuropsychiatric symptoms. Ginkgolide B is a platelet-activating factor (PAF) antagonist. Key safety concern: significant bleeding risk when combined with warfarin, aspirin, or NSAIDs. Rare seizure reports noted. Only standardized extracts (EGb761) should be used.
Dosage
120 mg · Morning · Can take on empty stomach
Key Interactions
10 verified interactions found
Both piracetam and ginkgo biloba exert mild antiplatelet and anticoagulant effects. Their combination may increase the risk of bleeding, particularly in patients on anticoagulant therapy or before surgery.
Use with caution. Avoid in patients on blood thinners (warfarin, aspirin, clopidogrel). Discontinue at least 2 weeks before surgery.
View details →Both Ginkgo and Vitamin E have antiplatelet/blood-thinning properties. Ginkgo via PAF antagonism, Vitamin E via thromboxane inhibition. Combined use may increase bleeding risk.
Use caution if on blood thinners. Consult healthcare provider before combining high doses.
View details →Ginkgo improves cerebral blood flow; Bacopa enhances synaptic signaling via bacoside action on serotonin and acetylcholine. Different mechanisms for cognitive enhancement.
Combine for complementary cognitive support.
View details →Ginkgo supports cerebral microcirculation; Lion's Mane promotes NGF for neurogenesis. Complementary: blood flow delivery + neuronal growth support.
Combine for brain health. No timing constraints.
View details →Ginkgo enhances cerebral blood flow; Phosphatidylserine supports neuronal membrane fluidity and cortisol regulation. Complementary cognitive support pathways.
Combine for memory and cognitive support.
View details →Scientific Sources
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- Ginkgo PAF antagonism and bleeding risk
- Vitamin E antiplatelet effects
- Ginkgo + bacopa cognitive combination study (2004)
- Nootropic herbs cognitive enhancers review (2023)
- Ginkgo + bacopa synergy study (2025)
- Neuroprotective herbs — Ginkgo + Hericium (2021)
- Nutrients and phytonutrients cognitive review (2021)
- Ginkgo + hericium cognitive study (2025)
- Ginkgo + phosphatidylserine cognitive combination (2024)
- Ginkgo biloba + phosphatidylserine cognitive study (2007)
- Ginkgo + phospholipid cognitive synergy (2016)
Frequently Asked Questions
What is Ginkgo biloba used for?
Ginkgo biloba leaf extract (EGb761: 24% flavonoids, 6% terpenoids) has been studied for cognitive decline and dementia.
What is the recommended dosage for Ginkgo biloba?
120 mg. Morning. Can take on empty stomach.
Does Ginkgo biloba interact with other supplements?
Ginkgo biloba has 10 verified interactions. Top: Piracetam, Vitamin E (Tocopherol).
When is the best time to take Ginkgo biloba?
Morning. Can take on empty stomach.
Is Ginkgo biloba safe to combine with other supplements?
Always check interactions before combining supplements. Use VitalStack to verify your full stack for free.
Check how Ginkgo biloba fits your full stack
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Check Your Stack →Not medical advice. VitalStack is not a medical device. For personalized health recommendations, consult a healthcare provider.