Arginine
Overview
L-arginine is a semi-essential amino acid and precursor to nitric oxide (NO) via nitric oxide synthase, mediating vasodilation, immune function, and wound healing. Used for cardiovascular support, erectile dysfunction, and exercise performance. GI side effects common at higher doses. Contraindicated in herpes simplex (promotes viral replication) and post-myocardial infarction. Caution with antihypertensive medications (additive blood pressure lowering). Do not combine with PDE5 inhibitors without medical supervision.
Dosage
3000 mg · Any time · Can take on empty stomach
Key Interactions
30 verified interactions found
Agmatine, derived from arginine, helps coordinate inflammatory responses and tissue repair through arginine-dependent pathways.
Agmatin wird im Körper aus Arginin gebildet; kombinierte Einnahme kann beide Wirkungen verstärken. Gesamtdosis begrenzen und nicht in Hochdosis kombinieren.
View details →Arginin-Supplementierung erhöht den Ornithin-Metabolismus und die Aktivität des Harnstoffzyklus. Hochdosierte kombinierte Einnahme kann den Harnstoffzyklus belasten.
Arginin-Supplementierung erhöht die Umwandlungsrate zu Ornithin. Bei gleichzeitiger Ornithin-Supplementierung Gesamtdosis anpassen; je ≤3g/Tag beider Substanzen gelten als sicher.
View details →Lysin und Arginin in Kombination können über hormonelle Mechanismen einen angstlösenden Effekt entfalten. Die gleichzeitige hochdosierte Einnahme beeinflusst Stresshormon-Reaktionen.
Arginin und Lysin konkurrieren um denselben intestinalen Transporter. Für optimale Aufnahme beider Substanzen mindestens 2h Abstand zwischen den Einnahmen einhalten.
View details →Leucine may reduce nitric oxide production from arginine, potentially affecting blood vessel function and cardiovascular health during insulin resistance.
Leucin kann die Stickstoffoxid-Synthese aus Arginin hemmen. Bei gezielter Arginin-Supplementierung (z.B. zur NO-Förderung) Leucin und Arginin zeitversetzt einnehmen.
View details →Both arginine and lysine are positively charged amino acids that share cationic amino acid transporters (CAT transporters). They compete for absorption in the intestine and across the blood-brain barrier. However, this competitive relationship is often therapeutic (arginine/lysine ratio affects herpes virus replication, immune function).
Spacing doses or consulting for intended therapeutic ratios recommended. Not universally contraindicated.
View details →Scientific Sources
- PubChem CID:6322
- Medicinal Plants That Modulate Nitric Oxide Synthase Activity: Implications in Inflammatio... (Drug Des Devel Ther, 2026)
- PubMed Batch-02
- PubMed Batch-02
- Agmatine: At the Crossroads of the Arginine Pathways (2003)
- Expression of the liver form of arginase in erythrocytes. (2002)
- Agmatine reverses ethanol consumption in rats: Evidences for an interaction with (2019)
- Nitric oxide involvement in additive antidepressant-like effect of agmatine and (2018)
- Agmatine attenuates chronic unpredictable mild stress-induced anxiety, depressio (2017)
- Urea cycle intermediate kinetics and nitrate excretion at normal and "therapeuti (1995)
- Orally supplemented L-arginine impairs amino acid absorption depending on dose i (2014)
- Arginine Auxotrophy Affects Siderophore Biosynthesis and Attenuates Virulence of (2020)
- Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized again (2010)
- ADP-ribosylation of human defensin HNP-1 results in the replacement of the modif (2009)
- Subchronic treatment with amino acid mixture of L-lysine and L-arginine modifies (2005)
- Oral arginine-lysine does not increase growth hormone or insulin-like growth fac (1993)
- The L-Arginine Transporter Solute Carrier Family 7 Member 2 Mediates the Immunop (2016)
- Delivery of Antisense Peptide Nucleic Acids to Cells by Conjugation with Small A (2014)
- Functional Interplay between Acetylation and Methylation of the RelA Subunit of (2010)
- l-Leucine and NO-mediated cardiovascular function (2014)
- Arginine transport in human erythroid cells: discrimination of CAT1 and 4F2hc/y+ (2009)
- Paraoxonase and susceptibility to organophosphorus poisoning in farmers dipping (2003)
- The heterodimeric amino acid transporter 4F2hc/y+LAT2 mediates arginine efflux i (2000)
- Stimulation of system y(+)-like amino acid transport by the heavy chain of human (1992)
- NIH Dietary Supplement Label Database (DSLD)
- PubChem Compound 6322
Frequently Asked Questions
What is Arginine used for?
L-arginine is a semi-essential amino acid and precursor to nitric oxide (NO) via nitric oxide synthase, mediating vasodilation, immune function, and wound healing.
What is the recommended dosage for Arginine?
3000 mg. Any time. Can take on empty stomach.
Does Arginine interact with other supplements?
Arginine has 30 verified interactions. Top: Agmatine, Ornithine.
When is the best time to take Arginine?
Any time. Can take on empty stomach.
Is Arginine safe to combine with other supplements?
Always check interactions before combining supplements. Use VitalStack to verify your full stack for free.
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Check Your Stack →Not medical advice. VitalStack is not a medical device. For personalized health recommendations, consult a healthcare provider.