Lysine
Overview
L-lysine (C6H14N2O2) is an essential amino acid required for collagen synthesis, carnitine biosynthesis, calcium absorption, and immune function. It competitively antagonizes L-arginine. Evidence for herpes simplex prophylaxis: effective primarily at doses >3 g/day; doses below 1 g/day show minimal effect without concurrent low-arginine diet. Generally well tolerated. Caution in cardiovascular or gallbladder disease. High doses may reduce arginine-dependent NO synthesis. No established upper limit.
Dosage
1000 mg · Any time · Can take on empty stomach
Key Interactions
21 verified interactions found
Lysin und Arginin in Kombination können über hormonelle Mechanismen einen angstlösenden Effekt entfalten. Die gleichzeitige hochdosierte Einnahme beeinflusst Stresshormon-Reaktionen.
Arginin und Lysin konkurrieren um denselben intestinalen Transporter. Für optimale Aufnahme beider Substanzen mindestens 2h Abstand zwischen den Einnahmen einhalten.
View details →Adjusting the valine-to-lysine ratio in the diet alters how efficiently amino acids are utilized for protein synthesis.
Lysin und Valin werden im Aminosäurestoffwechsel in optimalem Verhältnis benötigt. Ausgewogene Aminosäurezufuhr bevorzugen; nicht einseitig eine der beiden Substanzen hochdosieren.
View details →Both arginine and lysine are positively charged amino acids that share cationic amino acid transporters (CAT transporters). They compete for absorption in the intestine and across the blood-brain barrier. However, this competitive relationship is often therapeutic (arginine/lysine ratio affects herpes virus replication, immune function).
Spacing doses or consulting for intended therapeutic ratios recommended. Not universally contraindicated.
View details →Carnosine inhibits glycation-induced cross-linking of proteins containing lysine residues, protecting against advanced glycation end product formation.
Carnosin kann die Glycierung von Lysin in Proteinen hemmen und gemeinsam Anti-Aging-Effekte unterstützen. Kombination in Standarddosen ist unkritisch.
View details →Excessive lysine reduces arginine availability and decreases ornithine formation, impairing urea cycle function and causing orotic acid accumulation.
Überschuss an Lysin kann die Ornithin-Bildung in der Leber reduzieren. Bei gleichzeitiger Supplementierung nicht beide in Hochdosis kombinieren; je ≤3g/Tag sind unkritisch.
View details →Scientific Sources
- PubChem CID:5962
- Lysine for Herpes Simplex Prophylaxis: A Review of the Evidence. (Integr Med (Encinitas), 2017 Jun)
- pubmed_ncbi_api
- pubmed_ncbi_api
- Subchronic treatment with amino acid mixture of L-lysine and L-arginine modifies (2005)
- Oral arginine-lysine does not increase growth hormone or insulin-like growth fac (1993)
- The L-Arginine Transporter Solute Carrier Family 7 Member 2 Mediates the Immunop (2016)
- Delivery of Antisense Peptide Nucleic Acids to Cells by Conjugation with Small A (2014)
- Functional Interplay between Acetylation and Methylation of the RelA Subunit of (2010)
- Estimates of the optimum dietary ratio of standardized ileal digestible valine t (2009)
- Cellular uptake of valine by lactating porcine mammary tissue. (2000)
- The effect of dietary lysine and valine fed during lactation on sow and litter p (1997)
- A cross-inhibition of basic amino acid transport by neutral amino acids. (1969)
- On the catalytic mechanism of bacteriophage HK97 capsid crosslinking. (2017)
- Carnosine reacts with a glycated protein. (2000)
- Covalent cross-linking of glutathione and carnosine to proteins by 4-oxo-2-nonen (2009)
- Effect of feeding histidine and β-alanine on carnosine concentration, growth per (2021)
- Conditional deficiencies of ornithine or arginine. (1986)
- Dietary compliance in ornithine aminotransferase deficiency (2006)
- Hyperornithinemia with gyrate atrophy of the choroid and retina: a disturbance i (1981)
- Hereditary metabolic disorders of the urea cycle. (1971)
- Characteristics of lysine transport by isolated rat renal cortical tubule fragme (1987)
- NIH Dietary Supplement Label Database (DSLD)
- PubChem Compound 5962
Frequently Asked Questions
What is Lysine used for?
L-lysine (C6H14N2O2) is an essential amino acid required for collagen synthesis, carnitine biosynthesis, calcium absorption, and immune function.
What is the recommended dosage for Lysine?
1000 mg. Any time. Can take on empty stomach.
Does Lysine interact with other supplements?
Lysine has 21 verified interactions. Top: Arginine, Valine.
When is the best time to take Lysine?
Any time. Can take on empty stomach.
Is Lysine safe to combine with other supplements?
Always check interactions before combining supplements. Use VitalStack to verify your full stack for free.
Check how Lysine fits your full stack
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Check Your Stack →Not medical advice. VitalStack is not a medical device. For personalized health recommendations, consult a healthcare provider.