Agmatine
Overview
Agmatine (C5H14N4) is the decarboxylation product of L-arginine functioning as an endogenous neuromodulator. Mechanisms: NMDA receptor antagonism, imidazoline receptor agonism (analgesic/antidepressant), NOS inhibition, and alpha2-adrenoceptor modulation. A narrative review described it as particularly promising for major depression with strong preclinical evidence. Human clinical evidence remains limited. Also a polyamine precursor (spermidine, spermine). NMDA antagonism may interact with psychoactive medications. Generally well tolerated in available trials. No EFSA-authorized health claims.
Dosage
500 mg · Any time · Can take on empty stomach
Key Interactions
8 verified interactions found
Agmatine, derived from arginine, helps coordinate inflammatory responses and tissue repair through arginine-dependent pathways.
Agmatin wird im Körper aus Arginin gebildet; kombinierte Einnahme kann beide Wirkungen verstärken. Gesamtdosis begrenzen und nicht in Hochdosis kombinieren.
View details →Agmatine enhances the neurological effects of antipsychotic medications.
Agmatin kann die Wirkung von Dopamin-Antagonisten beeinflussen; eine direkte Interaktion mit Piperin ist nicht gesichert. Eine gleichzeitige Einnahme gilt als unbedenklich.
View details →Agmatine and L-NAME (a nitric oxide synthase blocker) both reduce the increase in L-citrulline levels, suggesting that nitric oxide synthesis is involved in citrulline production.
Agmatin kann den Citrullin-Spiegel im Blut senken, möglicherweise durch Hemmung der NO-Synthase. Eine gleichzeitige Einnahme beider Supplemente kann die NO-Produktionseffekte von Citrullin abschwächen; die klinische Relevanz ist gering.
View details →Lysine, ornithine, and arginine are ineffective at inhibiting agmatine transporter activity.
Lysin, Arginin und Ornithin konkurrieren mit Agmatin um denselben basischen Aminosäure-Transporter. Eine klinisch relevante Wechselwirkung bei Supplementdosierungen ist nicht bekannt.
View details →Ornithine, arginine, and lysine do not inhibit agmatine cellular uptake through the electroneutral transporter.
Ornithin, Arginin und Lysin konkurrieren mit Agmatin um denselben Transporter. Eine klinisch relevante Wechselwirkung bei Supplementdosierungen ist nicht bekannt.
View details →Scientific Sources
- PubChem CID:199
- Agmatine: multifunctional arginine metabolite and magic bullet in clinical neuroscience? (Biochem J, 2017 Jul 26)
- Agmatine: At the Crossroads of the Arginine Pathways (2003)
- Expression of the liver form of arginase in erythrocytes. (2002)
- Agmatine reverses ethanol consumption in rats: Evidences for an interaction with (2019)
- Nitric oxide involvement in additive antidepressant-like effect of agmatine and (2018)
- Agmatine attenuates chronic unpredictable mild stress-induced anxiety, depressio (2017)
- Psychopharmacological study of agmatine in behavioral tests of schizophrenia in (2012)
- Effect of agmatine on brain l-citrulline production during morphine withdrawal i (2007)
- Selective inhibition of inducible nitric oxide synthase by agmatine. (1995)
- Agmatine is transported into liver mitochondria by a specific electrophoretic me (2006)
- NIH Dietary Supplement Label Database (DSLD)
- PubChem Compound 199
Frequently Asked Questions
What is Agmatine used for?
Agmatine (C5H14N4) is the decarboxylation product of L-arginine functioning as an endogenous neuromodulator.
What is the recommended dosage for Agmatine?
500 mg. Any time. Can take on empty stomach.
Does Agmatine interact with other supplements?
Agmatine has 8 verified interactions. Top: Arginine, Piperin.
When is the best time to take Agmatine?
Any time. Can take on empty stomach.
Is Agmatine safe to combine with other supplements?
Always check interactions before combining supplements. Use VitalStack to verify your full stack for free.
Check how Agmatine fits your full stack
Verify interactions, get timing plans, and optimize your supplement routine — free.
Check Your Stack →Not medical advice. VitalStack is not a medical device. For personalized health recommendations, consult a healthcare provider.