Silymarin
Overview
Silymarin is a flavonolignan complex from milk thistle (Silybum marianum), standardized to 70–80% silymarin with silybin A (C25H22O10) as primary bioactive. Hepatoprotective via membrane stabilization, antioxidant activity, and NF-κB inhibition. A systematic review of 14 RCTs confirmed reduced liver enzymes (AST, ALT, ferritin) and iron overload in thalassemia patients. Broader evidence supports NAFLD/NASH and hepatoprotection from toxic damage. CYP3A4/CYP2C9 inhibitor — caution with statins, cyclosporine, warfarin. Phytosome formulations (Siliphos®) improve bioavailability. Generally well tolerated.
Dosage
420 mg · Any time · Can take on empty stomach
Key Interactions
11 verified interactions found
Silymarin and vitamin E together reduce lipid peroxidation markers (MDA) more effectively than either supplement alone.
Silymarin und Vitamin E können in Kombination die Lipidperoxidation stärker senken als Einzelsubstanzen. Die gleichzeitige Einnahme gilt als sicher; bei Lebererkrankungen empfiehlt sich ärztliche Begleitung.
View details →Silymarin and melatonin together protect kidney function by reducing renal oxidative damage and inflammation.
Silymarin und Melatonin besitzen beide antioxidative Eigenschaften und können sich gegenseitig beeinflussen. Eine gleichzeitige Einnahme ist nach aktuellem Kenntnisstand unbedenklich.
View details →Berberine and silymarin together have the strongest effect on lowering cholesterol and triglycerides.
Berberin und Silymarin kombiniert zeigen synergistische Effekte auf Cholesterin- und Triglycerid-Spiegel. Kombination in üblichen Dosen (Berberin ≤500mg, Silymarin ≤420mg) ist unkritisch.
View details →Combined selenium and silymarin treatment improves clinical outcomes and quality of life in prostate cancer patients by reducing oxidative stress markers.
Silymarin und Selen können in Kombination zur Lebergesundheit beitragen; eine tägliche Supplementierung wurde in einer klinischen Studie untersucht. Eine gleichzeitige Einnahme gilt als unbedenklich.
View details →Zinc nanoparticles enhance silymarin production and antioxidant defenses in plant tissue.
Zink kann laut präklinischer Daten die Silymarin-Produktion steigern und antioxidative Wirkungen verstärken. Eine gleichzeitige Einnahme von Zink und Silymarin in üblichen Dosierungen ist unbedenklich.
View details →Scientific Sources
- Comparative Effects of Silymarin and Vitamin E Supplementation on Oxidative Stre (2011)
- Role of Different Natural Antioxidants in the Modulation of mRNA-expression of A (2017)
- New mechanism in the modulation of carbon tetrachloride hepatotoxicity in rats u (2016)
- Inhibitory action of silymarin of lipid peroxide formation in rat liver mitochon (1977)
- Comparison of the Protective Effects of Melatonin and Silymarin Against Gentamic (2016)
- Protective Effects of Silymarin, Alone or in Combination with Chlorogenic Acid a (2016)
- Silymarin: A Novel Natural Agent to Restore Defective Pancreatic β Cells in Stre (2016)
- Berberine and Dyslipidemia: Different Applications and Biopharmaceutical Formula (2019)
- Metabolic effect of berberine–silymarin association: A meta‐analysis of randomiz (2019)
- Retrospective analysis of the effects of a highly standardized mixture of Berber (2017)
- Preliminary study about the possible glycemic clinical advantage in using a fixe (2013)
- The safety and efficacy of a silymarin and selenium combination in men after rad (2010)
- Interactive effects of zinc oxide nano particles and different light regimes on (2021)
- PubChem Compound 31553
Frequently Asked Questions
What is Silymarin used for?
Silymarin is a flavonolignan complex from milk thistle (Silybum marianum), standardized to 70–80% silymarin with silybin A (C25H22O10) as primary bioactive.
What is the recommended dosage for Silymarin?
420 mg. Any time. Can take on empty stomach.
Does Silymarin interact with other supplements?
Silymarin has 11 verified interactions. Top: Vitamin E (Tocopherol), Melatonin.
When is the best time to take Silymarin?
Any time. Can take on empty stomach.
Is Silymarin safe to combine with other supplements?
Always check interactions before combining supplements. Use VitalStack to verify your full stack for free.
Check how Silymarin fits your full stack
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Check Your Stack →Not medical advice. VitalStack is not a medical device. For personalized health recommendations, consult a healthcare provider.