Glutathione (GSH)

NAC is the rate-limiting precursor for endogenous glutathione synthesis. Supplemental glutathione provides direct GSH. NAC sustains intracellular levels while oral GSH provides immediate availability.

Can combine. NAC provides long-term GSH support, oral glutathione for acute boost.

Selenium is the cofactor for glutathione peroxidase (GPx) enzymes that use GSH to neutralize peroxides. Supplemental GSH + Selenium maximizes the GPx antioxidant system.

Combine for glutathione system optimization.

Vitamin C recycles oxidized GSSG back to reduced GSH. GSH regenerates oxidized ascorbate. Self-reinforcing antioxidant cycle.

Combine for antioxidant network.

Silymarin increases hepatic glutathione levels by up to 35%. Supplemental GSH provides direct antioxidant support. Together they maximize liver detoxification capacity.

Combine for comprehensive liver protection.

ALA regenerates glutathione from oxidized form and chelates heavy metals that deplete GSH.

Combine for antioxidant defense.